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anti-VEGF121 antibody :: Mouse anti-Human Vascular Endothelial Growth Factor 121 (VEGF121) Monoclonal Antibody

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Catalog # MBS2090565
Unit / Price
Scan QR to view Datasheet
  0.01 mg  /  $110 +1 FREE 8GB USB
  0.02 mg  /  $115 +1 FREE 8GB USB
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $195 +1 FREE 8GB USB
  0.2 mg  /  $255 +1 FREE 8GB USB
  1 mg  /  $590 +1 FREE 8GB USB
Product Name

Vascular Endothelial Growth Factor 121 (VEGF121), Monoclonal Antibody

Full Product Name

Monoclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
M32977 mRNA
3D Structure
ModBase 3D Structure for P15692
Clonality
Monoclonal
Isotype
IgG2b Kappa
Clone Number
C2
Host
Mouse
Species Reactivity
Human
Specificity
The antibody is a mouse monoclonal antibody raised against VEGF121. It has been selected for its ability to recognize VEGF121 in immunohistochemical staining and western blotting.
Purity/Purification
Protein A + Protein G affinity chromatography
Form/Format
Liquid
Concentration
1mg/mL (lot specific)
Immunogen
Recombinant Vascular Endothelial Growth Factor 121 (VEGF121)
Buffer Formulation
0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2059841
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-VEGF121 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-VEGF121 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-VEGF121 antibody
Western Blot: 0.5-5ug/mL
Immunocytochemistry in formalin fixed cells: 5-30ug/mL
Immunohistochemistry in formalin fixed frozen section: 5-30ug/mL
Immunohistochemistry in paraffin section: 5-30ug/mL

Western Blot (WB) of anti-VEGF121 antibody
Western Blot: Sample: Recombinant VEGF121, Human.
anti-VEGF121 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-VEGF121 antibody
DAB staining on IHC-P; Samples: Human Thyroid Cancer Tissue
anti-VEGF121 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-VEGF121 antibody
DAB staining on IHC-P; Samples: Human Lung Cancer Tissue.
anti-VEGF121 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-VEGF121 antibody
DAB staining on IHC-P; Samples: Human Liver Cancer Tissue.
anti-VEGF121 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-VEGF121 antibody
DAB staining on IHC-P; Samples: Human Liver Tissue.
anti-VEGF121 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for VEGF121. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,406 Da
NCBI Official Full Name
vascular endothelial growth factor A isoform a
NCBI Official Synonym Full Names
vascular endothelial growth factor A
NCBI Official Symbol
VEGFA  [Similar Products]
NCBI Official Synonym Symbols
VPF; VEGF; MVCD1
  [Similar Products]
NCBI Protein Information
vascular endothelial growth factor A
UniProt Protein Name
Vascular endothelial growth factor A
UniProt Synonym Protein Names
Vascular permeability factor; VPF
UniProt Gene Name
VEGFA  [Similar Products]
UniProt Synonym Gene Names
VEGF; VEGF-A; VPF  [Similar Products]
NCBI Summary for VEGF121
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
UniProt Comments for VEGF121
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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