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anti-VLDLR antibody :: Mouse anti-Human VLDL receptor, clone 1H10 Monoclonal Antibody

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Catalog # MBS135058
Unit / Price
  1 mg  /  $565 +1 FREE 8GB USB
  10 mg  /  $3,930 +4 FREE 8GB USB
anti-VLDLR antibody
Product Name

VLDL receptor, clone 1H10 (VLDLR), Monoclonal Antibody

Popular Item
Also Known As

Anti Human VLDL receptor, clone 1H10

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
845
Chromosome Location
Chromosome: 9; NC_000009.11 (2621793..2654485). Location: 9p24
OMIM
192977
3D Structure
ModBase 3D Structure for P98155
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
1H10
Host
Mouse
Species Reactivity
Human
Purity/Purification
IgG fraction
Form/Format
Frozen liquid
Concentration
4.74 mg/ml (lot specific)
Source
Hybridoma cell culture.
Immunogen
Recombinant fragment of soluble VLDL receptor containing ligand binding repeats 1-8 (sVLDLr1-8).
Target
Recognises the C-terminus of VLDL receptor ligand binding domain (191-355)
Target Molecular Weight
85,000
Antigen
Recombinant fragment of soluble VLDL receptor containing ligand repeats 1-8 (sVLDLr1-8).
Buffer
0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6
Extinction Coefficient
1.36
Aliquot
1 x 1.0mg
Preparation and Storage
Store at -70°C.
Shelf Life: 5 years from delivery
Shipping: Ships in Blue Ice.
Other Notes
Small volumes of anti-VLDLR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-VLDLR antibody
Monoclonal antibody produced in mouse. Useful for ELISA and western blot under non-reducing conditions. Binds to an epitope on the C-terminus of VLDL receptor ligand binding domain (amino acids 191-355, UniProtKB: locus VLDLR_HUMAN, accession P98155) and blocks apoE4 binding. Purified by immobilized Protein A. IgG1 class.
Applications Tested/Suitable for anti-VLDLR antibody
ELISA (EIA), Western Blot (WB), BL
NCBI/Uniprot data below describe general gene information for VLDLR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
160,000
NCBI Official Full Name
very low-density lipoprotein receptor isoform b
NCBI Official Synonym Full Names
very low density lipoprotein receptor
NCBI Official Symbol
VLDLR  [Similar Products]
NCBI Official Synonym Symbols
CARMQ1; CHRMQ1; VLDLRCH
  [Similar Products]
NCBI Protein Information
very low-density lipoprotein receptor; VLDL-R; VLDL receptor
UniProt Protein Name
Very low-density lipoprotein receptor
UniProt Gene Name
VLDLR  [Similar Products]
UniProt Synonym Gene Names
VLDL receptor; VLDL-R  [Similar Products]
UniProt Entry Name
VLDLR_HUMAN
NCBI Summary for VLDLR
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]
UniProt Comments for VLDLR
VLDLR: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation. Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1); also known as dysequilibrium syndrome (DES) or non- progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 9p24

Cellular Component: membrane; plasma membrane; integral to membrane; coated pit; receptor complex

Molecular Function: low-density lipoprotein receptor activity; very-low-density lipoprotein receptor activity; very-low-density lipoprotein binding; protein binding; apolipoprotein binding; calcium ion binding; glycoprotein binding; calcium-dependent protein binding

Biological Process: cholesterol metabolic process; nervous system development; receptor-mediated endocytosis; positive regulation of protein kinase activity; ventral spinal cord development; negative regulation of transcription from RNA polymerase II promoter; lipid transport; signal transduction; memory

Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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