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anti-RPL10 antibody :: Mouse anti-Human Wilm's Tumor Protein Monoclonal Antibody

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Catalog # MBS605645
Unit / Price
  0.1 mL  /  $580 +1 FREE 8GB USB
anti-RPL10 antibody
Product Name

Wilm's Tumor Protein (RPL10), Monoclonal Antibody

Also Known As

Wilm's Tumor Protein (Wilm's Tumor 1, WT 1, WT1, FWT1, GUD, WAGR, Wilms' Tumor, WT, WIT2, WT33)

Product Synonym Names
Anti -Wilm's Tumor Protein (Wilm's Tumor 1, WT 1, WT1, FWT1, GUD, WAGR, Wilms' Tumor, WT, WIT2, WT33)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: X; NC_000023.10 (153626571..153630680). Location: Xq28
OMIM
312173
3D Structure
ModBase 3D Structure for P27635
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
9F523
Host
Mouse
Species Reactivity
Human
Specificity
Species Crossreactivity: This antibody reacts with human. It is expected to react with mouse protein as well.
Purity/Purification
Purified
Purified
Form/Format
Supplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.
Immunogen
Human recombinant WT1 protein (residues 1-181). [Swiss-Prot# P19544]. Epitope: Residues 1-84.
Cellular Localization
Nuclear
Positive Control
293 and K562 cell lysates
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 3 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-RPL10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-RPL10 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-RPL10 antibody
Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry.
Dilution: Western Blot: ~ 55kD.
NCBI/Uniprot data below describe general gene information for RPL10. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,604 Da[Similar Products]
NCBI Official Full Name
Wilm's tumor-related protein
NCBI Official Synonym Full Names
ribosomal protein L10
NCBI Official Symbol
RPL10  [Similar Products]
NCBI Official Synonym Symbols
QM; L10; NOV; AUTSX5; DXS648; DXS648E; FLJ23544; FLJ27072; DKFZp686J1851
  [Similar Products]
NCBI Protein Information
60S ribosomal protein L10; OTTHUMP00000031945; OTTHUMP00000063212; OTTHUMP00000063213; OTTHUMP00000183506; OTTHUMP00000196447; tumor suppressor QM; laminin receptor homolog; Wilms tumor-related protein
UniProt Protein Name
60S ribosomal protein L10
UniProt Synonym Protein Names
Laminin receptor homolog; Protein QM; Tumor suppressor QM
Protein Family
UniProt Gene Name
RPL10  [Similar Products]
UniProt Synonym Gene Names
DXS648E; QM  [Similar Products]
UniProt Entry Name
RL10_HUMAN
NCBI Summary for RPL10
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as 'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Transcript variants utilizing alternative polyA signals exist. The variant with the longest 3' UTR overlaps the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq]
UniProt Comments for RPL10
RPL10: Defects in RPL10 are a cause of susceptibility to autism X-linked type 5 (AUTSX5). A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. RPL10 is involved in autism only in rare cases. Two hypomorphic variants affecting the translation process have been found in families with autism spectrum disorders, suggesting that aberrant translation may play a role in disease mechanisms. Belongs to the ribosomal protein L10e family.

Protein type: Translation; Ribosomal

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: membrane; endoplasmic reticulum; cytosol

Molecular Function: protein binding; structural constituent of ribosome

Biological Process: SRP-dependent cotranslational protein targeting to membrane; translational elongation; cellular protein metabolic process; translation; viral reproduction; translational initiation; mRNA catabolic process, nonsense-mediated decay; viral transcription; gene expression; translational termination; viral infectious cycle

Disease: Autism, Susceptibility To, X-linked 5
Precautions
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Disclaimer
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