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anti-WISP2 antibody :: Mouse anti-Human WISP2 Monoclonal Antibody

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Catalog # MBS246020
Unit / Price
  0.05 mg  /  $595 +1 FREE 8GB USB
Product Name

WISP2, Monoclonal Antibody

Popular Item
Full Product Name

Mouse Monoclonal [clone 1E11] (IgG2a,k) to Human WISP2

Product Synonym Names
Anti-WISP2 Antibody (clone 1E11) IHC-plus; WISP2; CCN5; CCN family member 5; CTGFL; CT58; CTGF-L; WISP-2; Human WISP2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
603399
3D Structure
ModBase 3D Structure for O76076
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
1E11
Host
Mouse
Species Reactivity
Human
Specificity
Human WISP2
Purity/Purification
Protein A purified
Form/Format
PBS, pH 7.4. Sourced in Ascites.
Concentration
0.5 mg/ml (lot specific)
Target Species
Human
Immunogen Description
WISP2 antibody was raised against recombinant protein
Antigen Type
Recombinant protein
Presentation
PBS, pH 7.4. Sourced in Ascites
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Other Notes
Small volumes of anti-WISP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-WISP2 antibody
WISP2 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
Applications Tested/Suitable for anti-WISP2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-WISP2 antibody
ELISA, IHC-P (5 ug/ml), WB (1:500 - 1:1000), ELISA (Optimal dilution to be determined by the researcher)
Usage: Western Blot: Transfected lysate, Recombinant protein.

Immunohistochemistry (IHC) of anti-WISP2 antibody
Anti-WISP2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-WISP2 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-WISP2 antibody
Western blot of WISP2 expression in transfected 293T cell line by WISP2 monoclonal antibody, clone 1E11.
anti-WISP2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for WISP2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,577 Da
NCBI Official Full Name
WNT1-inducible-signaling pathway protein 2
NCBI Official Synonym Full Names
WNT1 inducible signaling pathway protein 2
NCBI Official Symbol
WISP2  [Similar Products]
NCBI Official Synonym Symbols
CCN5; CT58; CTGF-L
  [Similar Products]
NCBI Protein Information
WNT1-inducible-signaling pathway protein 2; WISP-2; CCN family member 5; wnt-1 signaling pathway protein 2; connective tissue growth factor-like protein; connective tissue growth factor-related protein 58
UniProt Protein Name
WNT1-inducible-signaling pathway protein 2
UniProt Synonym Protein Names
CCN family member 5; Connective tissue growth factor-like protein; CTGF-L; Connective tissue growth factor-related protein 58
UniProt Gene Name
WISP2  [Similar Products]
UniProt Synonym Gene Names
CCN5; CT58; CTGFL; WISP-2; CTGF-L  [Similar Products]
UniProt Entry Name
WISP2_HUMAN
NCBI Summary for WISP2
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]
UniProt Comments for WISP2
WISP2: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production. Belongs to the CCN family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: extracellular space; proteinaceous extracellular matrix; plasma membrane

Molecular Function: integrin binding; heparin binding; insulin-like growth factor binding

Biological Process: cell-cell signaling; regulation of cell growth; cell adhesion; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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