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anti-ACAT2 antibody :: Mouse ACAT2 Monoclonal Antibody

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Catalog # MBS831394
Unit / Price
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  0.1 mL  /  $515 +1 FREE 8GB USB
Product Name

ACAT2, Monoclonal Antibody

Full Product Name

ACAT2 antibody

Product Synonym Names
Monoclonal ACAT2; Anti-ACAT2; Acetyl-Coenzyme A Acetyltransferase 2; ACAT2; ACAT 2; ACAT-2
Matching Pairs
Capture Antibody: ACAT2 Clone #1G6 (MBS831394)
Detection Antibody: ACAT2 Clone #5F7 (MBS830055)
Comments: Suitable pairing for Lateral Flow. Can also be used in ELISA
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
100678
3D Structure
ModBase 3D Structure for Q9BWD1
Clonality
Monoclonal
Isotype
IgG1
Clone Number
1G6
Host
Mouse
Species Reactivity
Human, Monkey
Purity/Purification
ACAT2 antibody was purified by affinity chromatography.
Form/Format
Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration
500 ug-1 mg/ml (lot specific)
Biological Significance
Acetyl-Coenzyme A acetyltransferase 2 is an enzyme involved in lipid metabolism. Reported patients with ACAT2 deficiency have shown severe mental retardation and hypotonus. The ACAT2 gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation.
Immunogen
ACAT2 antibody was raised in mouse using a full length recombinant protein of human ACAT2 (NP_005882) produced in HEK293T cells, as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-ACAT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACAT2 antibody
Mouse monoclonal ACAT2 antibody
Applications Tested/Suitable for anti-ACAT2 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
Application Notes for anti-ACAT2 antibody
FC: 1:100, IF: 1:100, IHC: 1:50

Western Blot (WB) of anti-ACAT2 antibody
Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant ACAT2 protein (Right) or empty vector (Left) detected with ACAT2 antibody
anti-ACAT2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ACAT2 antibody
Immunohistochemical analysis of ACAT2 protein in paraffin embedded Human liver tissue using ACAT2 antibody
anti-ACAT2 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-ACAT2 antibody
Immunofluorescent staining of COS7 cells transiently transfected with recombinant ACAT2 protein using ACAT2 antibody
anti-ACAT2 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for ACAT2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,643 Da
NCBI Official Full Name
acetyl-CoA acetyltransferase, cytosolic isoform 1
NCBI Official Synonym Full Names
acetyl-CoA acetyltransferase 2
NCBI Official Symbol
ACAT2  [Similar Products]
NCBI Protein Information
acetyl-CoA acetyltransferase, cytosolic
UniProt Protein Name
Acetyl-CoA acetyltransferase, cytosolic
UniProt Synonym Protein Names
Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase
UniProt Gene Name
ACAT2  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
THIC_HUMAN
NCBI Summary for ACAT2
The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
UniProt Comments for ACAT2
ACAT2: The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008]

Protein type: Lipid Metabolism - synthesis and degradation of ketone bodies; Lipid Metabolism - fatty acid; Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 2.3.1.9; Amino Acid Metabolism - lysine degradation; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - tryptophan; Acetyltransferase; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - propanoate

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: acetyl-CoA C-acetyltransferase activity

Biological Process: lipid metabolic process

Disease: Acetyl-coa Acetyltransferase-2 Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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