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anti-DR5 antibody :: anti-Human, Mouse DR5 Monoclonal Antibody

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Catalog # MBS475077
Unit / Price
  0.1 mL  /  $335 +1 FREE 8GB USB
Product Name

DR5, Monoclonal Antibody

Popular Item
Full Product Name

Anti-DR5 Mouse mAb

Product Synonym Names
Fas like protein; Apoptosis inducing protein TRICK2A/2B; Apoptosis inducing receptor TRAIL R2; CD 262; CD262; CD262 antigen; Cytotoxic TRAIL receptor 2; Death domain containing receptor for TRAIL/Apo 2L; Death domain containing receptor for TRAIL/Apo2L; Death receptor 5; DR 5; DR5; Fas like protein precursor; KILLER; KILLER/DR5; OTTHUMP00000123492; OTTHUMP00000123493; p53 regulated DNA damage inducible cell death receptor (killer); p53 regulated DNA damage inducible cell death receptor (killer); TNF related apoptosis inducing ligand receptor 2; TNF related apoptosis inducing ligand receptor 2; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TR10B_HUMAN; TRAIL R2; TRAIL receptor 2; TRAIL-R2; TRAILR2; TRANCER; TRICK2; TRICK2A; TRICK2B; TRICKB; Tumor necrosis factor receptor like protein ZTNFR9; Tumor necrosis factor receptor like protein ZTNFR9; Tumor necrosis factor receptor superfamily member 10b; Tumor necrosis factor receptor superfamily, member 10b; ZTNFR9
Product Gene Name
Product Synonym Gene Name
tnfrsf10b; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5.[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
AF018657 mRNA
3D Structure
ModBase 3D Structure for O14763
Clonality
Monoclonal
Isotype
IgG1
Clone Number
7F4-F8-G11
Host
Mouse
Source: Human
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purified
Form/Format
Purified mouse monoclonal in PBS (pH 7.4) containing with 0.02% sodium azide, 0.1mg/mlBSA and 50% glycerol.
Concentration
0.4mg/ml (lot specific)
Immunogen
Purified recombinant human DR5 protein fragments expressed in E Coli.
Sensitivity
This antibody detects endogenous levels of DR5 and does not cross-react with related proteins.
Sequence Similarities
Contains 1 death domain.Contains 3 TNFR-Cys repeats.
Subunit Structure
Homotrimer.Can interact with TRADD and RIPK1.
Subcellular Location
Membrane; Single-pass type I membrane protein.
Other Notes
Small volumes of anti-DR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DR5 antibody
Entrez Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain.This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal.Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.[provided by RefSeq, Mar 2009]
Applications Tested/Suitable for anti-DR5 antibody
Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-DR5 antibody
WB: 1:500-1:2000
ICC: 1:100

Western Blot (WB) of anti-DR5 antibody
Western blot detection of DR5 in Mouse kindey, Mouse brain, HCT116 and Hela cell lysates using DR5 mouse mAb (1:500-1:2000 diluted).Predicted band size:40/48KDa.Observed band size:40/48KDa.
anti-DR5 antibody Western Blot (WB) (WB) image
Immunocytochemistry (ICC) of anti-DR5 antibody
Immunocytochemistry of HeLa cells fixed by Paraformaldehyde and using DR5 mouse mAb diluted 1:100.
anti-DR5 antibody Immunocytochemistry (ICC) (ICC) image
NCBI/Uniprot data below describe general gene information for DR5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 10B isoform 1
NCBI Official Synonym Full Names
TNF receptor superfamily member 10b
NCBI Official Symbol
TNFRSF10B  [Similar Products]
NCBI Official Synonym Symbols
DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5
  [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 10B
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 10B
UniProt Synonym Protein Names
Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD_antigen: CD262
UniProt Gene Name
TNFRSF10B  [Similar Products]
UniProt Synonym Gene Names
DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; TRAIL receptor 2; TRAIL-R2  [Similar Products]
NCBI Summary for DR5
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Comments for DR5
TRAIL-R2: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Homotrimer. Can interact with TRADD and RIPK1. Regulated by p53/TP53. Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: cell surface; integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; tumor necrosis factor receptor activity

Biological Process: caspase activation; cell surface receptor linked signal transduction; immune response; induction of apoptosis via death domain receptors; inflammatory response; multicellular organismal development; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide

Disease: Squamous Cell Carcinoma, Head And Neck
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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