NP_037379
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,914 Da
NCBI Official Full Name
serine protease HTRA2, mitochondrial isoform 1 preproprotein
NCBI Official Synonym Full Names
HtrA serine peptidase 2
NCBI Protein Information
serine protease HTRA2, mitochondrial
UniProt Protein Name
Serine protease HTRA2, mitochondrial
UniProt Synonym Protein Names
High temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; Serine protease 25; Serine proteinase OMI
UniProt Synonym Gene Names
NCBI Summary for HtrA2/Omi
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
UniProt Comments for HtrA2/Omi
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Product References and Citations for anti-HtrA2/Omi antibody
Miller L., et al., (1999) Trends Cell Biol. 9:323-28; Zumbrunn J., et al., (1996) FABS Lett. 398:187-92; Gui-Ying N., et al., (2003) Biochem. J. 371:39-48
Research Articles on HtrA2/Omi
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Products associated with anti-HtrA2/Omi antibody
Pathways associated with anti-HtrA2/Omi antibody
Diseases associated with anti-HtrA2/Omi antibody
Organs/Tissues associated with anti-HtrA2/Omi antibody
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