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Mouse Amyloid Beta Peptide 42 Monoclonal Antibody

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Catalog # MBS592143
Unit / Price
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  0.5 mg  /  $445 +1 FREE 8GB USB
Product Name

Amyloid Beta Peptide 42, Monoclonal Antibody

Popular Item
Full Product Name

mAb anti-Amyloid Beta Peptide 42

Product Synonym Names
Beta amyloid peptide 42; Mouse monoclonal antibody to C-terminal of amyloid beta peptide 42 (Abeta42)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
CA10 C11
Host
Mouse
Species Reactivity
Human, Other primates, Mouse, Rat
The antibody does not cross react with amyloid beta peptide 40 in dot blotting and ELISA. Cross-reactivity to amyloid beta peptide 43 is about 5% in ELISA.
Specificity
This antibody recognizes the C-terminal sequence (MVGGVVIA) of Abeta42 and full length Abeta42.
Beta amyloid peptide 42
Purity/Purification
Protein G affinity purified
Form/Format
Lyophilized from a solution in 0.01M PBS, pH 7.2
Target Protein
C-terminal of amyloid beta peptide 42
Immunogen
KLH conjugated to a short peptide (MVGGVVIA) with amino acid sequence corresponding to the C-terminal of Abeta42
Myeloma
Sp2/0-Ag14
Light Chain
Kappa
Reconstitution
Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
Research Area
Aging and neurodegenerative diseases
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-Amyloid Beta Peptide 42 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Amyloid Beta Peptide 42 antibody
Amyloid beta peptide 42 (AB42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer's disease. AB42 and AB40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. AB42 (42 amino acids) is very fibrillogenic. The beta pleated structure of AB42 consitituents the intial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that AB42 contibutes to the pathogenesis of Alzheimer's. One propsition is that the deposition of amyloid fibril onto the brain tissues results in Alzheimer's disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimer's disease. One proposition is that deposition of amyloid fibril onto the brain tissue results in Alzheimer's disease. Another is that the neurotoxicity of AB42 oligomer is the cause of the disease.
Applications Tested/Suitable for anti-Amyloid Beta Peptide 42 antibody
ELISA (EIA)
ELISA: In combination with capturer anti-amyloid peptide N-terminal antibody (mAb clone NT 4A2), the antibody can detect Abeta42 in Sandwich ELISA assay.
Immuno-blot: Detect Abeta42 on dot blot using anti- Abeta42 clone CA9 10C11 (1mug/mL) on 10ng /dot of Abeta40 or Abeta42.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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