• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-ACTN1 antibody :: Mouse a-actinin Monoclonal Antibody

Scan QR to view Datasheet
Catalog # MBS2548904
Unit / Price
Scan QR to view Datasheet
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

a-actinin (ACTN1), Monoclonal Antibody

Full Product Name

a-actinin Monoclonal Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
X15804 mRNA
3D Structure
ModBase 3D Structure for P12814
Clonality
Monoclonal
Isotype
IgG
Clone Number
1D4
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Protein A Purification
Concentration
1mg/mL (lot specific)
Immunogen
Recombinant Protein of a-actinin of ACTN1
Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ACTN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACTN1 antibody
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
Applications Tested/Suitable for anti-ACTN1 antibody
Immunohistochemistry (IHC) Paraffin (IHC-p)
Application Notes for anti-ACTN1 antibody
IHC: 1:100-200

Immunohistochemistry (IHC) of anti-ACTN1 antibody
Immunohistochemistry of paraffin-embedded Human kidney tissue using a-actinin Monoclonal Antibody at dilution of 1:200.
anti-ACTN1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ACTN1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
107,141 Da
NCBI Official Full Name
alpha-actinin-1 isoform b
NCBI Official Synonym Full Names
actinin alpha 1
NCBI Official Symbol
ACTN1  [Similar Products]
NCBI Official Synonym Symbols
BDPLT15
  [Similar Products]
NCBI Protein Information
alpha-actinin-1
UniProt Protein Name
Alpha-actinin-1
UniProt Synonym Protein Names
Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1
Protein Family
UniProt Gene Name
ACTN1  [Similar Products]
NCBI Summary for ACTN1
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ACTN1
ACTN1: a cytoskeletal protein of the spectrin superfamily. An actin-binding protein with multiple roles in different cell types. A nonmuscle isoform structurally similar to the erythroid beta spectrin gene.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q24.1|14q22-q24

Cellular Component: actin filament; brush border; cell projection; cytoplasm; cytosol; extracellular exosome; extracellular region; extracellular space; fascia adherens; focal adhesion; intercellular junction; intracellular; plasma membrane; pseudopodium; ruffle; stress fiber; Z disc

Molecular Function: actin filament binding; calcium ion binding; double-stranded RNA binding; integrin binding; ion channel binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; protein homodimerization activity; vinculin binding

Biological Process: actin crosslink formation; actin filament bundle formation; actin filament network formation; actin filament organization; focal adhesion assembly; negative regulation of cell motility; platelet activation; platelet degranulation; platelet formation; regulation of apoptosis

Disease: Bleeding Disorder, Platelet-type, 15
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000