• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-Kcnmb2 antibody :: Mouse BK Beta2 Monoclonal Antibody

Scan QR to view Datasheet
Catalog # MBS804398
Unit / Price
Scan QR to view Datasheet
  0.1 mg  /  $440 +1 FREE 8GB USB
Product Name

BK Beta2 (Kcnmb2), Monoclonal Antibody

Full Product Name

BK Beta2 Antibody: ATTO 680

Product Synonym Names
KCNMB2; Calcium-activated potassium channel subunit beta-2; BK channel subunit beta-2; BKbeta2; Calcium-activated potassium channel; subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; K(VCA)beta-2; Maxi K channel subunit beta-2; Slo-beta-2
Matching Pairs
Unconjugated Antibody: BK Beta2 Clone #S53-32 (MBS800649)
ATTO 680 Conjugated Antibody: BK Beta2 Clone #S53-32 (MBS804398)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9CZM9
Clonality
Monoclonal
Isotype
IgG1
Clone Number
S53-32
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Protein G Purified
Concentration
1mg/mL (lot specific)
Conjugate
ATTO 680
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Preparation and Storage
-20 degree C
Other Notes
Small volumes of anti-Kcnmb2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Kcnmb2 antibody
Background Info: No cross-reactivity against BKBeta1, BKBeta3 or BKBeta4.

Scientific Background: BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release (3). A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia (4). This has major implications on other physiological processes in tissues other than the brain.
Product Categories/Family for anti-Kcnmb2 antibody
Applications Tested/Suitable for anti-Kcnmb2 antibody
Western (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Application Notes for anti-Kcnmb2 antibody
1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)

Immunohistochemistry (IHC) of anti-Kcnmb2 antibody
Immunohistochemistry analysis using Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody, Clone S53-32. Tissue: backskin. Species: Mouse. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Lower epidermal cells positive, but quite dull.
anti-Kcnmb2 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-Kcnmb2 antibody
Western Blot analysis of Human Cell line lysates showing detection of BK Beta2 Potassium Channel protein using Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody, Clone S53-32. Load: 15 ug. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT.
anti-Kcnmb2 antibody Western Blot (WB) (WB) image
Immunocytochemistry/Immunofluorescence (ICC/IF) of anti-Kcnmb2 antibody
Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody, Clone S53-32. Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20 degree C. Primary Antibody: Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dottiness and dull.
anti-Kcnmb2 antibody Immunocytochemistry/Immunofluorescence (ICC/IF) (ICC) image
NCBI/Uniprot data below describe general gene information for Kcnmb2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
27,120 Da[Similar Products]
NCBI Official Full Name
calcium-activated potassium channel subunit beta-2
NCBI Official Synonym Full Names
potassium large conductance calcium-activated channel, subfamily M, beta member 2
NCBI Official Symbol
Kcnmb2  [Similar Products]
NCBI Official Synonym Symbols
2700049B16Rik; 3110031N04Rik
  [Similar Products]
NCBI Protein Information
calcium-activated potassium channel subunit beta-2; BKbeta2; slo-beta-2; k(VCA)beta-2; BK channel subunit beta-2; maxi K channel subunit beta-2; charybdotoxin receptor subunit beta-2; calcium-activated potassium channel, subfamily M subunit beta-2
UniProt Protein Name
Calcium-activated potassium channel subunit beta-2
UniProt Synonym Protein Names
BK channel subunit beta-2; BKbeta2; Calcium-activated potassium channel, subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; K(VCA)beta-2; Maxi K channel subunit beta-2; Slo-beta-2
UniProt Gene Name
Kcnmb2  [Similar Products]
UniProt Synonym Gene Names
BKbeta2  [Similar Products]
UniProt Entry Name
KCMB2_MOUSE
UniProt Comments for Kcnmb2
KCNMB2: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: voltage-gated potassium channel complex; membrane; integral to plasma membrane; integral to membrane

Molecular Function: calcium-activated potassium channel activity; potassium channel regulator activity; potassium channel activity

Biological Process: regulation of action potential; synaptic transmission; transport; generation of action potential; ion transport; detection of calcium ion; potassium ion transport
Product References and Citations for anti-Kcnmb2 antibody
1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. 2. www.iochannels.org 3. Wulf-Johansson H., et al. (2009) Brain Res. 1292: 1- 13. 4. Lee U.S., and Cui J. (2009) J Physiol. 587(7): 1481- 1489.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000