View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-c-erbB-2/HER-2 antibody :: Mouse c-erbB-2/HER-2 Monoclonal Antibody Catalog # MBS462228 Unit / Price 0.1 mg / $330 +1 FREE 8GB USB 5x0.1 mg / $1,310 +1 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name c-erbB-2/HER-2, Monoclonal Antibody Full Product Name Mouse anti c-erbB-2/HER-2 Product Synonym Names Ms anti-c-erbB-2/HER-2; human epidermal growth factor Receptor 2 (Her-2); p185erbB2; MLN19; C-erbB-2; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; CD340 antigen Product Gene Name anti-c-erbB-2/HER-2 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Clonality Monoclonal Isotype IgG1, k Clone Number SPM495 Host Mouse Species Reactivity Human, Mouse, Rat Specificity This antibody recognizes Her-2 protein. It cross-reacts with human, rat and mouse. The other species was not tested. Purity/Purification The Mouse IgG is purified by Isotyping-specific Affinity Purification. Form/Format This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer Concentration Size: 100 ug/200 ul (lot specific) Antigen Preparation A synthetic peptide corresponding to the C-terminus of Her2 protein. This sequence is identical in human, mouse, and rat. Positive Control SK-BR-3 cell lysate Cellular Location Membrane Preparation and Storage The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles. Other Notes Small volumes of anti-c-erbB-2/HER-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-c-erbB-2/HER-2 antibody Oncoprotein Her-2/Neu/ c-erbB-2 belongs to one of the four members of the ErbB receptor family. They are transmembrane receptor-like tyrosine kinases which can be autophosphorylated without ligand binding process when it is overexpressed in breast cancers. Her2 is an important biomarker in breast cancer identification. The antibodies/ heregulin can suppress phosphorylation of HER2 on tyrosine Y1248. Endogenous anti-HER2 antibodies can effectively suppress HER2 kinase activity and downstream signaling to inhibit the transformed phenotype of HER2-expressing tumor cells. Thus, anti-Her2 antibodies have been used widely in the treatment of the breast cancer and other carcinomas. Applications Tested/Suitable for anti-c-erbB-2/HER-2 antibody ELISA, Western Blot, Immunohistochemistry Application Notes for anti-c-erbB-2/HER-2 antibody Western Blot: 0.1-1 ug/mlELISA: 0.01-0.1 ug/mlImmunoprecipitation: 2-5 ug/mlImmunohistochemistry: 2-5 ug/mlFlow Cytometry: 5-10 ug/ml Testing Data of anti-c-erbB-2/HER-2 antibody TOP Molecular Weight ~185 kDa TOP Product References and Citations for anti-c-erbB-2/HER-2 antibody Xiao-Feng Le et al (2000) Anti-HER2 Antibody and Heregulin Suppress Growth of HER2-Overexpressing Human Breast Cancer Cells through Different Mechanisms. Clinical Cancer Research Vol. 6, 260-270. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP