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anti-CAT antibody :: Mouse CAT / Catalase Monoclonal Antibody

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Catalog # MBS245275
Unit / Price
  0.05 mL  /  $530 +1 FREE 8GB USB
Product Name

CAT / Catalase, Monoclonal Antibody

Full Product Name

Mouse Monoclonal (IgG2a,k) to Human CAT / Catalase

Product Synonym Names
Anti-CAT / Catalase Antibody IHC-plus; CAT; Catalase; Human CAT; Catalase
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 614097
3D Structure
ModBase 3D Structure for P04040
Clonality
Monoclonal
Isotype
IgG2a,k
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Purified
Form/Format
HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Recombinant human CAT / Catalase purified from E Coli.
Immunogen Type
Recombinant protein
Immunogen
CAT / Catalase antibody was raised against recombinant human CAT / Catalase purified from E Coli.
Preparation and Storage
+4 degree C or -20 degree C, Avoid repeated freezing and thawing.
Other Notes
Small volumes of anti-CAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CAT antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-CAT antibody
IHC-P (1:50), WB (1:100 - 1:1000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-CAT antibody
Anti-Catalase antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
anti-CAT antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-CAT antibody
 
anti-CAT antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for CAT. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,756 Da
NCBI Official Full Name
catalase
NCBI Official Synonym Full Names
catalase
NCBI Official Symbol
NCBI Protein Information
catalase
UniProt Protein Name
Catalase
UniProt Gene Name
UniProt Entry Name
CATA_HUMAN
NCBI Summary for CAT
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for CAT
Catalase: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Homotetramer. Belongs to the catalase family.

Protein type: Oxidoreductase; Apoptosis; Energy Metabolism - methane; EC 1.11.1.6; Mitochondrial; Amino Acid Metabolism - tryptophan; Hydrolase; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: peroxisomal membrane; Golgi apparatus; peroxisomal matrix; focal adhesion; intracellular membrane-bound organelle; membrane; endoplasmic reticulum; lysosome; plasma membrane; mitochondrial intermembrane space; peroxisome; cytosol

Molecular Function: antioxidant activity; oxidoreductase activity, acting on peroxide as acceptor; protein homodimerization activity; enzyme binding; catalase activity; metal ion binding; heme binding; NADP binding; aminoacylase activity; receptor binding

Biological Process: cholesterol metabolic process; nucleobase, nucleoside and nucleotide metabolic process; hemoglobin metabolic process; purine base metabolic process; protein homotetramerization; activation of NF-kappaB transcription factor; positive regulation of phosphoinositide 3-kinase cascade; osteoblast differentiation; response to vitamin E; response to reactive oxygen species; triacylglycerol metabolic process; response to hyperoxia; UV protection; hydrogen peroxide catabolic process; ureteric bud development; inhibition of NF-kappaB transcription factor; positive regulation of cell division; response to hypoxia; aerobic respiration; purine nucleotide catabolic process; protein tetramerization; negative regulation of apoptosis; aging

Disease: Acatalasemia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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