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anti-Cacnb2 antibody :: Mouse Cav-beta 2 Ca+2 Channel Monoclonal Antibody

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Catalog # MBS190548
Unit / Price
  0.1 mg  /  $395 +1 FREE 8GB USB
Testing Data
Product Name

Cav-beta 2 Ca+2 Channel (Cacnb2), Monoclonal Antibody

Popular Item
Full Product Name

Anti-Cav beta 2 Ca+2 Channel Monoclonal Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
189-205
Chromosome Location
Chromosome: 17; NC_005116.2 (88832905..89078870). Location: 17q12.3
3D Structure
ModBase 3D Structure for Q8VGC3
Clonality
Monoclonal
Isotype
IgG1
Clone Number
S8b-1
Host
Mouse
Species Reactivity
Human, mouse, rat
Specificity
Cav beta 2 Ca+2 Channel
This antibody recognizes human, mouse, and rat Cavbeta2. It does not cross-react with Cav beta1, Cav beta3, or Cav beta4.
Form/Format
100ug in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.
Antigen
Synthetic peptide corresponding to aa 189-205 of rat Cavbeta2 (RSPKPSANSVTSPHSKE) (accession no.NP_446303).
Dilution Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.
Other Notes
Small volumes of anti-Cacnb2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forCacnb2purchase
Ion channels like anti Cav beta 2 calcium channel - CACNB - are localized to cell plasma membrane and activation with ligands results in cellular responses. With limited information about molecular subunit composition for active voltage dependent calcium channels, MyBiosource's mouse monoclonal antibody recognized beta specifically and not gamma or alpha. Cell experiments to determine functional properties commonly utilize stable transfections of human or mouse gene plasmid lenti activation system expression or ShRNA plasmid sc knockdown. The ability to distinguish subtypes of expression in either stably puromycin type selection or stable gene silencing puromyocin selection requires our pan species [ human mouse rat ] CACNB2 antibody. Compared to rabbit antibodies, our Cav B2 calcium channel voltage antibody recognizes protein in lysates, IHC and is suitable for ELISA kits development. Value pricing, rapid shipping and promotional items make this product and all our products top sellers worldwide. Find us at MyBiosource.com.
Related Product Information for
anti-Cacnb2 antibody
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Cavbeta subunits are involved in the transport of the pore-forming alpha1 subunit to the plasma membrane. They also shield an ER Retention signal on the alpha1 subunit, thereby guiding the poreforming subunit to the target membrane.
Applications Tested/Suitable for anti-Cacnb2 antibody
Immunoblot; Immunohistochemistry; Immunocytochemistry; Immunofluorescence
Application Notes for anti-Cacnb2 antibody
Immunoblotting: use at 1-10ug/ml. A band of ~78kDa is detected. Immunohistochemistry and Immunocytochemistry: use at 0.1-1ug/ml. Immunofluorescence: use at 1-10ug/ml. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain lysate

Testing Data of anti-Cacnb2 antibody
anti-Cacnb2 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for Cacnb2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
73,226 Da[Similar Products]
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit beta-2
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, beta 2 subunit
NCBI Official Symbol
Cacnb2  [Similar Products]
NCBI Official Synonym Symbols
Cacnlb2
  [Similar Products]
NCBI Protein Information
voltage-dependent L-type calcium channel subunit beta-2; CAB2; calcium channel voltage-dependent subunit beta 2
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit beta-2
UniProt Synonym Protein Names
Calcium channel voltage-dependent subunit beta 2
UniProt Gene Name
Cacnb2  [Similar Products]
UniProt Synonym Gene Names
Cacnlb2  [Similar Products]
UniProt Entry Name
CACB2_RAT
NCBI Summary for Cacnb2
auxillary subunit of the L-type Ca(2+) channel [RGD]
UniProt Comments for Cacnb2
CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Cellular Component: voltage-gated calcium channel complex; sarcolemma

Molecular Function: voltage-gated calcium channel activity; protein domain specific binding; calcium channel regulator activity; high voltage-gated calcium channel activity; phosphoprotein binding; protein kinase binding

Biological Process: synaptic transmission; visual perception; calcium ion transport; positive regulation of calcium ion transport; neuromuscular junction development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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