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anti-CBLB antibody :: Mouse CBLB Monoclonal Antibody

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Catalog # MBS2527223
Unit / Price
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  0.06 mL  /  $220 +1 FREE 8GB USB
  0.12 mL  /  $290 +1 FREE 8GB USB
  0.2 mL  /  $435 +1 FREE 8GB USB
Western Blot (WB)
Product Name

CBLB, Monoclonal Antibody

Full Product Name

CBLB Monoclonal Antibody

Product Synonym Names
AI429560; AI851073; Cas Br M (murine) ecotropic retroviral transforming sequence b; Casitas B lineage lymphoma b; Casitas B lineage lymphoma proto oncogene b; Casitas B-lineage lymphoma proto-oncogene b; Cbl b; CBLB; CBLB; DKFZp686J10223; DKFZp779A0729; DKFZp779F1443; E3 ubiquitin protein ligase CBL B; E3 ubiquitin-protein ligase CBL-B; EC 6.3.2.-; FLJ36865; FLJ41152; Nbla00127; RING finger protein 56; RNF56; SH3 binding protein CBL B; SH3-binding protein CBL-B; Signal transduction protein CBL B; Signal transduction protein CBL-B
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
604491 geneneXtProt; the human protein knowledge platformMore
3D Structure
ModBase 3D Structure for Q13191
Clonality
Monoclonal
Isotype
IgG3
Clone Number
2D3A2
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Protein A purification
Concentration
1mg/mL (lot specific)
Immunogen
Fusion protein of CBLB
Buffer
PBS with 0.02% sodium azide, 50% glycerol, PH7.3
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CBLB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CBLB antibody
CBLB(E3 ubiquitin-protein ligase CBL-B) is also known as RNF56 and plays a necessary role to prevent the inappropriate activation of NF-B in response to lipopolysaccharide and to polymicrobial sepsis. CBLB can be phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell stimulation. It also has a crucial role in the prevention of chronic inflammation and autoimmunity. This protein has 3 isoforms produced by alternative splicing.
Applications Tested/Suitable for anti-CBLB antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-CBLB antibody
WB: 1:500-1:5000
IHC: 1:100-1:400
IF: 1:50-1:500

Western Blot (WB) of anti-CBLB antibody
Western Blot analysis of RAW 264.7 cells using CBLB Monoclonal Antibody at dilution of 1:1000
anti-CBLB antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for CBLB. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated: 109kDa
Observed: 110kDa
NCBI Official Full Name
E3 ubiquitin-protein ligase CBL-B isoform b
NCBI Official Synonym Full Names
Cbl proto-oncogene B
NCBI Official Symbol
NCBI Official Synonym Symbols
Cbl-b; RNF56; Nbla00127
  [Similar Products]
NCBI Protein Information
E3 ubiquitin-protein ligase CBL-B
UniProt Protein Name
E3 ubiquitin-protein ligase CBL-B
UniProt Synonym Protein Names
Casitas B-lineage lymphoma proto-oncogene b; RING finger protein 56; RING-type E3 ubiquitin transferase CBL-BCurated; SH3-binding protein CBL-B; Signal transduction protein CBL-B
UniProt Gene Name
UniProt Synonym Gene Names
RNF56  [Similar Products]
NCBI Summary for CBLB
This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
UniProt Comments for CBLB
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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