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anti-Erbb4 antibody :: Mouse erbB4 Monoclonal Antibody

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Catalog # MBS606828
Unit / Price
  0.1 mg  /  $615 +1 FREE 8GB USB
anti-Erbb4 antibody
Product Name

erbB4, Monoclonal Antibody

Also Known As

erbB4 (c-erbB4, HER4)

Product Synonym Names
Anti -erbB4 (c-erbB4, HER4)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000067.5 (68086540..69154633, complement). Location: 1 C3; 1 35.1 cM
3D Structure
ModBase 3D Structure for O88459
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
9H232
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes human c-erB-4/Her 4 cytoplasmic domain of the protein (residues 1250-1264), a member of the EGF receptor (type 1) family involved in cell growth regulation. Expression or function may be altered in human cancers.
Purity/Purification
Purified
Purified
Form/Format
Supplied as a liquid in PBS, pH 7.6, 0.01% sodium azide.
Immunogen
Synthetic peptide sequence RSTLQHPDYLQEYST from the cytoplasmic domain of the protein, residues 1250-1264. Cellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein. Species sequence homology: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-Erbb4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Erbb4 antibody
erbB4/HER4 is the fourth member of the human epidermal growth factor receptor (EGFR) family that is frequently overexpressed in a variety of aggressive epithelial carcinomas. Its extracellular domain is most similar to the orphan receptor HER3, whereas its cytoplasmic kinase domain exhibits 79% and 77% identity with EGFR and HER2, respectively. HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain and cerebellum.
Applications Tested/Suitable for anti-Erbb4 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-Erbb4 antibody
Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry.
Dilution: Western Blot: 1:500-1:1000 detects erbB-4 on 10ug of A431 lysates.
Immunohistochemistry: formalin-fixed, paraffin-embedded sections.
NCBI/Uniprot data below describe general gene information for Erbb4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
erbB4
NCBI Official Synonym Full Names
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
NCBI Official Symbol
Erbb4  [Similar Products]
NCBI Official Synonym Symbols
Her4; c-erbB-4
  [Similar Products]
NCBI Protein Information
receptor tyrosine-protein kinase erbB-4; OTTMUSP00000030425; OTTMUSP00000030426; OTTMUSP00000030427; avian erythroblastosis oncogene B 4; proto-oncogene-like protein c-ErbB-4
UniProt Protein Name
EGF-like growth factor receptor ErbB4 extracellular domain
UniProt Gene Name
Erbb4  [Similar Products]
UniProt Entry Name
O88459_MOUSE
UniProt Comments for Erbb4
HER4: a receptor tyrosine kinase of the EGFR family. Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Heterodimerizes and signals with other EGF receptors. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with WWOX. May act as a tumor suppressor: overexpressed in head and neck cancer , but downregulated in renal cancer, papillary carcinoma, high-grade gliomas and invasive breast cancer. 3 alternatively-spliced isoforms of the human protein have been reported.

Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; Kinase, protein; TK group; EGFR family

Cellular Component: mitochondrion; membrane; basolateral plasma membrane; cytoplasm; postsynaptic density; integral to membrane; plasma membrane; caveola; nucleus; receptor complex; lipid raft

Molecular Function: transferase activity; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; ATP binding; epidermal growth factor receptor binding; protein kinase activity

Biological Process: lactation; synapse maturation; peptidyl-tyrosine phosphorylation; apoptosis; positive regulation of transcription, DNA-dependent; heart development; protein amino acid autophosphorylation; multicellular organismal development; embryonic pattern specification; signal transduction; protein amino acid phosphorylation; olfactory bulb interneuron differentiation; regulation of cell migration; positive regulation of glucose import; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; neural crest cell migration; positive regulation of cardiac muscle cell proliferation; nervous system development; cell migration; cell fate commitment; transcription, DNA-dependent; positive regulation of synaptic transmission, GABAergic; central nervous system morphogenesis; positive regulation of tyrosine phosphorylation of Stat5 protein; mitochondrial fragmentation during apoptosis; phosphorylation; surfactant homeostasis; positive regulation of epithelial cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-Erbb4 antibody
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