O88459
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UniProt Related Accession #
NCBI Official Full Name
erbB4
NCBI Official Synonym Full Names
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
NCBI Protein Information
receptor tyrosine-protein kinase erbB-4; OTTMUSP00000030425; OTTMUSP00000030426; OTTMUSP00000030427; avian erythroblastosis oncogene B 4; proto-oncogene-like protein c-ErbB-4
UniProt Protein Name
EGF-like growth factor receptor ErbB4 extracellular domain
UniProt Entry Name
O88459_MOUSE
UniProt Comments for Erbb4
HER4: a receptor tyrosine kinase of the EGFR family. Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Heterodimerizes and signals with other EGF receptors. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with WWOX. May act as a tumor suppressor: overexpressed in head and neck cancer , but downregulated in renal cancer, papillary carcinoma, high-grade gliomas and invasive breast cancer. 3 alternatively-spliced isoforms of the human protein have been reported.
Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; Kinase, protein; TK group; EGFR family
Cellular Component: mitochondrion; membrane; basolateral plasma membrane; cytoplasm; postsynaptic density; integral to membrane; plasma membrane; caveola; nucleus; receptor complex; lipid raft
Molecular Function: transferase activity; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; ATP binding; epidermal growth factor receptor binding; protein kinase activity
Biological Process: lactation; synapse maturation; peptidyl-tyrosine phosphorylation; apoptosis; positive regulation of transcription, DNA-dependent; heart development; protein amino acid autophosphorylation; multicellular organismal development; embryonic pattern specification; signal transduction; protein amino acid phosphorylation; olfactory bulb interneuron differentiation; regulation of cell migration; positive regulation of glucose import; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; neural crest cell migration; positive regulation of cardiac muscle cell proliferation; nervous system development; cell migration; cell fate commitment; transcription, DNA-dependent; positive regulation of synaptic transmission, GABAergic; central nervous system morphogenesis; positive regulation of tyrosine phosphorylation of Stat5 protein; mitochondrial fragmentation during apoptosis; phosphorylation; surfactant homeostasis; positive regulation of epithelial cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; negative regulation of apoptosis
Research Articles on Erbb4
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Pathways associated with anti-Erbb4 antibody
Diseases associated with anti-Erbb4 antibody
Organs/Tissues associated with anti-Erbb4 antibody
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