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anti-Hsp90 antibody :: Hsp90 Monoclonal Antibody

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Catalog # MBS475175
Unit / Price
  0.1 mL  /  $335 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Hsp90, Monoclonal Antibody

Popular Item
Full Product Name

Anti-Hsp90 Mouse mAb

Product Synonym Names
D6S182; FLJ26984; FLJ31884; Heat shock 86 kDa; heat shock 90kDa protein 1 alpha; Heat shock protein 90kDa alpha cytosolic class A member 1; Heat shock protein 90kDa alpha cytosolic class B member 1; Heat shock protein HSP 90 alpha; Heat shock protein HSP 90 beta; Heat shock protein HSP 90-alpha; HS90A_HUMAN; HSP 84; HSP 86; Hsp 90; HSP84; HSP86; Hsp89; Hsp90; HSP90 Beta; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSP90N; HSPC1; HSPC2; HSPCA; HSPCAL1; HSPCAL4; HSPCB; HSPN; LAP2; Lipopolysaccharide associated protein2; LPS associated protein 2; NY REN 38 antigen; Renal carcinoma antigen NY-REN-38
Product Synonym Gene Name
EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4.[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
X15183 mRNA
3D Structure
ModBase 3D Structure for P07900
Clonality
Monoclonal
Isotype
IgG1
Clone Number
4B6-G2-H6
Host
Mouse
Source: Human
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purified
Form/Format
Purified mouse monoclonal in PBS (pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Concentration
2.25mg/ml (lot specific)
Immunogen
Purified recombinant human HSP90AA1 protein fragments expressed in E Coli
Sensitivity
This antibody detects endogenous levels of Hsp90 alpha and Hsp90 beta.
Sequence Similarities
Belongs to the heat shock protein 90 family.
Subunit Structure
Homodimer.Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C STIP1.Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34.Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex.Interacts with CHORDC1 and DNAJC7.Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems.Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity
Subcellular Location
Cytoplasm. Melanosome. Note:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Other Notes
Small volumes of anti-Hsp90 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Hsp90 antibody
Entrez Summary: The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer.The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones.Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
Applications Tested/Suitable for anti-Hsp90 antibody
Western Blot (WB)
Application Notes for anti-Hsp90 antibody
WB: 1:2000

Western Blot (WB) of anti-Hsp90 antibody
Western blot detection of Hsp90 in Hela, 3T3, C6, K562 and A549 cell lysates using Hsp90 mouse mAb (1:2000 diluted).Exposion time: 4min.Predicted band size:90KDa.Observed band size:90KDa.
anti-Hsp90 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for Hsp90. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
90
NCBI Official Full Name
heat shock protein HSP 90-alpha isoform 1
NCBI Official Synonym Full Names
heat shock protein 90 alpha family class A member 1
NCBI Official Symbol
HSP90AA1  [Similar Products]
NCBI Official Synonym Symbols
EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p
  [Similar Products]
NCBI Protein Information
heat shock protein HSP 90-alpha
UniProt Protein Name
Heat shock protein HSP 90-alpha
UniProt Synonym Protein Names
Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38
Protein Family
UniProt Gene Name
HSP90AA1  [Similar Products]
UniProt Synonym Gene Names
HSP90A; HSPC1; HSPCA; HSP 86; HSP86; LAP-2; LPS-associated protein 2  [Similar Products]
NCBI Summary for Hsp90
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for Hsp90
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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