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anti-MICU1 antibody :: Mouse MICU1 Monoclonal Antibody

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Catalog # MBS9400198
Unit / Price
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  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $255 +1 FREE 8GB USB
Product Name

MICU1, Monoclonal Antibody

Popular Item
Full Product Name

MICU1 Monoclonal Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
605084
3D Structure
ModBase 3D Structure for Q9BPX6
Clonality
Monoclonal
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Specificity
The antibody detects endogenous MICU1 protein.
Purity/Purification
The antibody was affinity-purified from antiserum by affinity-chromatography
Form/Format
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Concentration
1 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant Protein
Target Name
MICU1
Preparation and Storage
Store at -20 degree C/1 year
Other Notes
Small volumes of anti-MICU1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-MICU1 antibody
Applications Tested/Suitable for anti-MICU1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MICU1 antibody
Western blotting: 1:1000-2000
Immunohistochemistry: 1:100-200

Western Blot (WB) of anti-MICU1 antibody
Western blot analysis of 1) MCF7, 2) Mouse Brain Tissue, 3) Rat Brain Tissue using MICU1 Monoclonal Antibody.
anti-MICU1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-MICU1 antibody
Immunohistochemical analysis of paraffin-embedded Human Lung Carcinoma using MICU1 Monoclonal Antibody.
anti-MICU1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for MICU1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55kd
NCBI Official Full Name
calcium uptake protein 1, mitochondrial isoform 2
NCBI Official Synonym Full Names
mitochondrial calcium uptake 1
NCBI Official Symbol
MICU1  [Similar Products]
NCBI Official Synonym Symbols
CALC; EFHA3; MPXPS; CBARA1
  [Similar Products]
NCBI Protein Information
calcium uptake protein 1, mitochondrial
UniProt Protein Name
Calcium uptake protein 1, mitochondrial
UniProt Synonym Protein Names
Atopy-related autoantigen CALC; ara CALC; Calcium-binding atopy-related autoantigen 1; Allergen: Hom s 4
Protein Family
UniProt Gene Name
MICU1  [Similar Products]
UniProt Synonym Gene Names
CALC; CBARA1; ara CALC  [Similar Products]
UniProt Entry Name
MICU1_HUMAN
NCBI Summary for MICU1
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]
UniProt Comments for MICU1
MICU1: Key regulator of mitochondrial calcium uptake required for calcium entry into mitochondrion. May act as a calcium sensor via its EF-hand domains, gating the activity of a calcium channel partner. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Belongs to the MICU1 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Membrane protein, integral; Calcium-binding

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial intermembrane space; intracellular

Molecular Function: identical protein binding; protein binding; protein heterodimerization activity; calcium ion binding

Biological Process: mitochondrial calcium ion homeostasis; defense response; mitochondrial calcium ion transport; protein homooligomerization; elevation of mitochondrial calcium ion concentration

Disease: Myopathy With Extrapyramidal Signs
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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