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anti-MYL2 antibody :: Mouse MYL2 Monoclonal Antibody

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Catalog # MBS245437
Unit / Price
  0.05 mL  /  $530 +1 FREE 8GB USB
Product Name

MYL2, Monoclonal Antibody

Also Known As

Mouse Monoclonal [clone AT3B2] (IgG2b,k) to Human MYL2

Product Synonym Names
Anti-MYL2 Antibody (clone AT3B2) IHC-plus; MYL2; MLC2; Myosin light chain 2; MLC-2; RLC of myosin; CMH10; MLC-2v; Human MYL2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
166
OMIM
gene 608758
3D Structure
ModBase 3D Structure for P10916
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
AT3B2
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Specificity
human MYL2 (1-166aa)
Purity/Purification
Protein G Purified
Form/Format
PBS, pH 7.4, 0.1% sodium azide
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Recombinant human MYL2 (1-166aa) purified from E Coli
Immunogen Type
Recombinant protein
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Other Notes
Small volumes of anti-MYL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MYL2 antibody
MYL2 encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
Applications Tested/Suitable for anti-MYL2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-MYL2 antibody
ELISA, IHC-P (5 ug/ml), WB (1:1000 - 1:2000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-MYL2 antibody
Anti-MYL2 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-MYL2 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-MYL2 antibody
Western analysis of mouse liver extracts
anti-MYL2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for MYL2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,789 Da
NCBI Official Full Name
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
NCBI Official Synonym Full Names
myosin, light chain 2, regulatory, cardiac, slow
NCBI Official Symbol
NCBI Official Synonym Symbols
MLC2; CMH10
  [Similar Products]
NCBI Protein Information
myosin regulatory light chain 2, ventricular/cardiac muscle isoform; MLC-2; MLC-2v; RLC of myosin; myosin light chain 2; regulatory light chain of myosin; cardiac ventricular myosin light chain 2; slow cardiac myosin regulatory light chain 2; myosin, light polypeptide 2, regulatory, cardiac, slow
UniProt Protein Name
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
MLC-2; MLC-2v  [Similar Products]
UniProt Entry Name
MLRV_HUMAN
NCBI Summary for MYL2
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
UniProt Comments for MYL2
MRLC2V: myosin regulatory light chain 2, ventricular/cardiac muscle isoform. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.

Protein type: Contractile

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: sarcomere; cytoskeleton; myofibril; myosin complex; cytosol; A band; actin cytoskeleton

Molecular Function: actin monomer binding; protein binding; structural constituent of muscle; calcium ion binding; myosin heavy chain binding

Biological Process: muscle cell fate specification; heart contraction; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; cardiac myofibril assembly; negative regulation of cell growth; muscle fiber development; muscle filament sliding; cardiac muscle contraction; post-embryonic development

Disease: Cardiomyopathy, Familial Hypertrophic, 10
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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