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anti-PDCD1 antibody :: Mouse PD-1 Monoclonal Antibody

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Catalog # MBS150009
Unit / Price
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  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

PD-1 (PDCD1), Monoclonal Antibody

Popular Item
Full Product Name

PD-1 Antibody [12A7D7]

Product Synonym Names
PD-1 Antibody [12A7D7] : PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death 1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 605218
3D Structure
ModBase 3D Structure for Q15116
Clonality
Monoclonal
Isotype
IgG1
Clone Number
12A7D7
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Purity/Purification
PD-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
A ~150 amino acid recombinant protein from near the amino terminus of mouse PD-1.
Accession No.
EDL39922
Buffer
PD-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
PD-1 monoclonal antibody can be stored at -20 degree C, stable for one year.
Other Notes
Small volumes of anti-PDCD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PDCD1 antibody
PD-1 Monoclonal Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Applications Tested/Suitable for anti-PDCD1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC-P)
Application Notes for anti-PDCD1 antibody
PD-1 antibody can be used for detection of PD-1 by Western blot at 1 ug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL.
Optimal dilutions for each application to be determined by the researcher.

Positive Control: MBS153298-PD-1 Recombinant Protein.

Western Blot (WB) of anti-PDCD1 antibody
Western blot analysis of PD-1 in A-20 cell lysate with PD-1 antibody at 1 μg/mL.
anti-PDCD1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PDCD1 antibody
Immunohistochemistry of PD-1 in mouse brain tissue with PD-1 antibody at 2.5 μg/mL.
anti-PDCD1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PDCD1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,647 Da
NCBI Official Full Name
programmed cell death 1
NCBI Official Synonym Full Names
programmed cell death 1
NCBI Official Symbol
Pdcd1  [Similar Products]
NCBI Official Synonym Symbols
PD-1; Pdc1; Ly101
  [Similar Products]
NCBI Protein Information
programmed cell death protein 1; mPD-1; protein PD-1
UniProt Protein Name
Programmed cell death protein 1
UniProt Synonym Protein Names
CD_antigen: CD279
UniProt Gene Name
PDCD1  [Similar Products]
UniProt Synonym Gene Names
PD1; Protein PD-1; hPD-1  [Similar Products]
UniProt Entry Name
PDCD1_HUMAN
UniProt Comments for PDCD1
PDCD1: a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse 'exhausted' T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells.

Protein type: Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: signal transducer activity; protein binding

Biological Process: apoptosis; multicellular organismal development; T cell costimulation; signal transduction; humoral immune response

Disease: Systemic Lupus Erythematosus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-PDCD1 antibody
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