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anti-TG antibody :: Mouse Thyroglobulin Monoclonal Antibody

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Catalog # MBS4380244
Unit / Price
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  0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
  0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
  0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

Thyroglobulin (TG), Monoclonal Antibody

Popular Item
Full Product Name

Thyroglobulin (Thyroidal Cell Marker)

Product Synonym Names
AITD3, hTG, TDH3, Tg, Tgn
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P01266
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
r2H11
Host
Mouse
Species Reactivity
Human, Mouse, Rat. Others not known.
Specificity
MAb r2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by MAb 6E1. Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Immunogen
Human thyroid follicular cells
Cellular Localization
Cytoplasmic and Secreted
Hu-chromosome Location
8q24.22
Positive Control
Thyroid
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Other Notes
Small volumes of anti-TG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TG antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Formalin
Application Notes for anti-TG antibody
FC/FACS: 0.5-1ug/million cells
IHC-F: 0.1-0.2ug/ml; 30 min at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.

Immunohistochemistry (IHC) of anti-TG antibody
Formalin-fixed, paraffin-embedded human Thyroid stained with Thyroglobulin Mouse Recombinant Monoclonal Antibody (r2H11).
anti-TG antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TG. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
660kDa (Dimeric Form)
NCBI Official Full Name
thyroglobulin
NCBI Official Synonym Full Names
thyroglobulin
NCBI Official Symbol
NCBI Official Synonym Symbols
TGN; AITD3
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NCBI Protein Information
thyroglobulin
UniProt Protein Name
Thyroglobulin
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
NCBI Summary for TG
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
UniProt Comments for TG
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Product References and Citations for anti-TG antibody
Endocrinol. 127: 419430 (1990). Moll. Cell. Endocrinol 66: 199205 (1989). Bellet, D, et al. J Clin Endocrin Metab 1983; 56:530-533. Ossendorp FA, et. al. Journal of Immunological Methods, 1989, 120(2):191-200.

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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