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anti-TRPM2 antibody :: Mouse TRPM2 Monoclonal Antibody

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Catalog # MBS608280
Unit / Price
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  0.1 mg  /  $580 +1 FREE 8GB USB
anti-TRPM2 antibody
Product Name

TRPM2, Monoclonal Antibody

Popular Item
Full Product Name

TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2, Estrogen Responsive Element Associated Gene 1, Estrogen-responsive Element-associated Gene 1 Protein, EREG1, KNP3, Long Transient Receptor Potential Channel 2, LTRPC 2, LTRPC2, LTRPC

Product Synonym Names
Anti -TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2, Estrogen Responsive Element Associated Gene 1, Estrogen-responsive Element-associated Gene 1 Protein, EREG1, KNP3, Long Transient Receptor Potential Channel 2, LTRPC 2, LTRPC2, LTRPC
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 21; NC_000021.8 (45773484..45862964). Location: 21q22.3
OMIM
603749
3D Structure
ModBase 3D Structure for Q9HCX4
Clonality
Monoclonal
Isotype
IgG1
Clone Number
10F775
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes human TrpC7. Species Crossreactivity: mouse and rat
Purity/Purification
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide, 50% glycerol.
Concentration
1 mg/ml (lot specific)
Immunogen
Synthetic peptide corresponding to aa 845-862 of human TRPC7
Grade
Affinity Purified
Important Note for small quantities
Liquids: Apparent volume may be reduced due to evaporation. Add buffer to nominal volume and dilute per instructions. During shipment, small volume products may have adhered to the interior surface of the vial. To recover the maximum amount of product,centrifuge the vial lightly for 1-3 minutes and use a fine tipped pipette for removal. To recover the maximum amount of total product, wash the vial with your assay buffer/diluent. Small volumes of product (less than or equal to 25ul) should be diluted for complete product recovery.
Powders: During shipment, small volume products may have adhered to the interior surface of the vial. To recover the maximum amount of product, centrifuge the vial lightly. To recover the maximum amount of total product, wash the vial with your assay buffer/diluent. Small volumes ~25-50ul should be diluted for complete product recovery
Preparation and Storage
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-TRPM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TRPM2 antibody
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical force.
Applications Tested/Suitable for anti-TRPM2 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)
Other applications not yet tested.
Application Notes for anti-TRPM2 antibody
Recommended Dilution:

Western Blot: 1ug/ml detects TrpC7 in 10ug of rat brain lyste using goat anti-mouse IgG (HRP) as secondary antibody.
Immunohistochemistry: 0.1-1ug/ml
Immunofluorescence: 1-10ug/ml

Optimal dilutions to be determined by the researcher.
NCBI/Uniprot data below describe general gene information for TRPM2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
transient receptor potential cation channel subfamily M member 2
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily M, member 2
NCBI Official Symbol
TRPM2  [Similar Products]
NCBI Official Synonym Symbols
KNP3; EREG1; TRPC7; LTRPC2; NUDT9H; NUDT9L1; MGC133383
  [Similar Products]
NCBI Protein Information
transient receptor potential cation channel subfamily M member 2; LTrpC-2; OTTHUMP00000038504; OTTHUMP00000038505; OTTHUMP00000109530; OTTHUMP00000207883; transient receptor potential channel 7; long transient receptor potential channel 2; estrogen-responsive element-associated gene 1 protein
UniProt Protein Name
Transient receptor potential cation channel subfamily M member 2
UniProt Synonym Protein Names
Estrogen-responsive element-associated gene 1 protein; Long transient receptor potential channel 2; LTrpC-2; LTrpC2; Transient receptor potential channel 7
UniProt Gene Name
TRPM2  [Similar Products]
UniProt Synonym Gene Names
EREG1; KNP3; LTRPC2; TRPC7  [Similar Products]
UniProt Entry Name
TRPM2_HUMAN
NCBI Summary for TRPM2
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq]
UniProt Comments for TRPM2
TRPM2: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.1.13; Membrane protein, multi-pass; Membrane protein, integral; Hydrolase; Transporter; Channel, calcium

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: ADP-ribose diphosphatase activity; calcium channel activity; manganese ion transmembrane transporter activity; sodium channel activity

Biological Process: response to hydroperoxide; metabolic process; calcium ion transport; transmembrane transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-TRPM2 antibody
 Reference Product  PubMed Publications
 TRPC6 antibody  >28 publications with TRPM2 and TRPC6
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