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anti-IL-1beta antibody :: Mouse IL-1beta Monoclonal Antibody

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Catalog # MBS592009
Unit / Price
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  0.5 mg  /  $490 +1 FREE 8GB USB
anti-IL-1beta antibody
Product Name

IL-1beta, Monoclonal Antibody

Popular Item
Full Product Name

mAb anti-Human IL-1beta

Product Synonym Names
Interleukin-1 Beta (IL-1beta); Interleukin-1 Beta (IL-1b); Mouse monoclonal antibody to human Interleukin-1 beta (IL-1beta)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
147720
Clonality
Monoclonal
Isotype
IgM,k
Clone Number
464
Host
Mouse
Species Reactivity
Human. Other species not tested
Does not show any cross reaction with recombinant human IL-1alpha, recombinant murine IL-1alpha or IL-1beta.
Specificity
Reactive with natural and recombinant human Interleukin-1 Beta (IL-1beta)
Purity/Purification
Protein G affinity purified
Form/Format
Lyophilized from a solution in 0.01M PBS, pH 7.2.
Target Protein
Human IL-1beta
Immunogen
Purified recombinant human IL-1beta
Myeloma
Sp2/0-Ag14
Light Chain
Kappa
Reconstitution
Double distillated water is recommended to reconstitute the antibody.
Research Area
Cytokine, Inflammation
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-IL-1beta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IL-1beta antibody
Interleukin 1 Beta (IL-1Beta) shares the IL-1 receptor with other cytokines in IL-1 family. It is primarily produced by activated macrophage as a proprotein, which is cleaved by caspase 1 to become active. Like IL-1 Alpha, IL-1Beta is an important mediator of innate immunity. IL-1Beta stimulates lymphocyte proliferation and the production of TNF-Alpha, IL-6 and IL-8. IL-1Beta and TNF-Alpha can synergically act at NGkB and mitogen kinases including JNKs and p38 MARKs, thus leading to the selective expression of genes for immunity and inflammation.
Applications Tested/Suitable for anti-IL-1beta antibody
ELISA (EIA)
Application Notes for anti-IL-1beta antibody
ELISA: React with IL-1beta
NCBI/Uniprot data below describe general gene information for IL-1beta. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,748 Da
NCBI Official Full Name
interleukin-1 beta proprotein
NCBI Official Synonym Full Names
interleukin 1, beta
NCBI Official Symbol
NCBI Official Synonym Symbols
IL-1; IL1F2; IL1-BETA
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NCBI Protein Information
interleukin-1 beta; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta
UniProt Protein Name
Interleukin-1 beta
UniProt Synonym Protein Names
Catabolin
UniProt Gene Name
UniProt Entry Name
IL1B_HUMAN
NCBI Summary for IL-1beta
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
UniProt Comments for IL-1beta
IL1B: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Monomer. Belongs to the IL-1 family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 2q14

Cellular Component: extracellular space; extracellular region; cytosol; secretory granule

Molecular Function: protein domain specific binding; interleukin-1 receptor binding; cytokine activity

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; negative regulation of MAP kinase activity; positive regulation of nitric oxide biosynthetic process; activation of MAPK activity; positive regulation of transcription, DNA-dependent; positive regulation of interleukin-2 biosynthetic process; germ cell programmed cell death; negative regulation of insulin receptor signaling pathway; positive regulation of NF-kappaB import into nucleus; positive regulation of lipid catabolic process; fever; positive regulation of membrane protein ectodomain proteolysis; response to carbohydrate stimulus; activation of NF-kappaB transcription factor; cell-cell signaling; positive regulation of phagocytosis; positive regulation of T cell mediated immunity; positive regulation of T cell proliferation; neutrophil chemotaxis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of heterotypic cell-cell adhesion; positive regulation of mitosis; smooth muscle adaptation; interleukin-1 beta production; positive regulation of interleukin-6 production; positive regulation of angiogenesis; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of lipid metabolic process; sequestering of triacylglycerol; positive regulation of histone phosphorylation; apoptosis; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK cascade; signal transduction; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of interleukin-8 production; positive regulation of protein export from nucleus; negative regulation of cell proliferation; negative regulation of lipid catabolic process; hyaluronan biosynthetic process; protein kinase B signaling cascade; lipopolysaccharide-mediated signaling pathway; regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; response to ATP; positive regulation of interferon-gamma production; positive regulation of chemokine biosynthetic process; positive regulation of prostaglandin secretion; positive regulation of fever; positive regulation of histone acetylation; immune response; positive regulation of protein amino acid phosphorylation; regulation of insulin secretion; embryo implantation

Disease: Gastric Cancer, Hereditary Diffuse
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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