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anti-CD163 antibody :: Mouse CD163 Monoclonal Antibody

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Catalog # MBS530501
Unit / Price
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  0.25 mg  /  $865 +1 FREE 8GB USB
Immunohistochemistry
Product Name

CD163, Monoclonal Antibody

Full Product Name

CD163 antibody (biotin)

Product Synonym Names
Monoclonal CD163; Anti-CD163; CD 163; CD-163; CD163
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
605545
3D Structure
ModBase 3D Structure for Q86VB7
Clonality
Monoclonal
Isotype
IgG1
Clone Number
RM3/1
Host
Mouse
Species Reactivity
Non-Human Primates
Specificity
Human
Form/Format
Lyophilized from PBS, pH 7.2, with 10mg/ml BSA, and 0.01% thimerosal.
Biological Significance
CD163 is a scavenger receptor for the haemoglobin-haptoglobin complex, and is upregulated by glucocorticoids and IL-10. The extracellular portion of the receptor is regularly shed and can be found in the circulation. An important function of CD163 seems to be in the adhesion of monocytes to activated endothelial cells.
Tag/Conjugate
Biotin
Immunogen
CD163 antibody (biotin) was raised in mouse using human monocytes as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-CD163 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD163 antibody
Mouse monoclonal CD163 antibody (biotin)
Applications Tested/Suitable for anti-CD163 antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Formalin, Western Blot (WB)
Application Notes for anti-CD163 antibody
IHC-F: 2 ug/ml

Immunohistochemistry of anti-CD163 antibody
Immunohistochemical staining using CD163 antibody
Human placenta frozen tissue section
anti-CD163 antibody Immunohistochemistry (IHC) image
NCBI/Uniprot data below describe general gene information for CD163. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
124,958 Da
NCBI Official Full Name
CD163
NCBI Official Synonym Full Names
CD163 molecule
NCBI Official Symbol
CD163  [Similar Products]
NCBI Official Synonym Symbols
M130; MM130
  [Similar Products]
NCBI Protein Information
scavenger receptor cysteine-rich type 1 protein M130
UniProt Protein Name
Scavenger receptor cysteine-rich type 1 protein M130
UniProt Synonym Protein Names
Hemoglobin scavenger receptor; CD_antigen: CD163
UniProt Gene Name
CD163  [Similar Products]
UniProt Synonym Gene Names
M130; sCD163  [Similar Products]
UniProt Entry Name
C163A_HUMAN
NCBI Summary for CD163
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for CD163
CD163: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: integral to plasma membrane; plasma membrane; extracellular region

Molecular Function: protein binding; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; acute-phase response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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