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anti-CD55 antibody :: Mouse CD55 Monoclonal Antibody

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Catalog # MBS245102
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

CD55, Monoclonal Antibody

Also Known As

Mouse Monoclonal [clone MEM-118] (IgM) to Human CD55

Product Synonym Names
Anti-CD55 Antibody (clone MEM-118) IHC-plus; CD55; CD55 antigen; Decay-accelerating factor; TC; CR; CROM; DAF; Human CD55
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
381
OMIM
gene 613793
3D Structure
ModBase 3D Structure for P08174
Clonality
Monoclonal
Isotype
IgM
Clone Number
MEM-118
Host
Mouse
Species Reactivity
Human, Primate
Specificity
HPB-ALL human T cell line
Purity/Purification
Gel filtration
Form/Format
PBS, 15 mM sodium azide, approx., pH 7.4.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Cells.
Immunogen
CD55 antibody was raised against cells.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Other Notes
Small volumes of anti-CD55 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD55 antibody
Decay-accelerating Factor (CD55) is one of the three proteins protecting cells from autologous lysis by complement. The others are: membrane cofactor protein (MCP; CD46) and an inhibitor of the membrane attack complex formation (CD59).
Applications Tested/Suitable for anti-CD55 antibody
Immunohistochemistry (IHC - Paraffin), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Application Notes for anti-CD55 antibody
Flo, IHC-P (10 ug/ml), IP
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-CD55 antibody
Anti-CD55 antibody IHC of human skin, pilosebaceous unit. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-CD55 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CD55. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,038 Da
NCBI Official Full Name
complement decay-accelerating factor isoform 1 preproprotein
NCBI Official Synonym Full Names
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
NCBI Official Symbol
NCBI Official Synonym Symbols
CR; TC; DAF; CROM
  [Similar Products]
NCBI Protein Information
complement decay-accelerating factor; CD55 antigen
UniProt Protein Name
Complement decay-accelerating factor
UniProt Synonym Protein Names
CD_antigen: CD55
UniProt Gene Name
UniProt Synonym Gene Names
CR; DAF  [Similar Products]
UniProt Entry Name
DAF_HUMAN
NCBI Summary for CD55
This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]
UniProt Comments for CD55
CD55: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Belongs to the receptors of complement activation (RCA) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Cell surface

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: cell surface; integral to plasma membrane; extracellular region; plasma membrane; lipid raft

Molecular Function: viral receptor activity; protein binding; lipid binding

Biological Process: respiratory burst; elevation of cytosolic calcium ion concentration; entry of virus into host cell; negative regulation of complement activation; regulation of complement activation; innate immune response; complement activation, classical pathway; regulation of lipopolysaccharide-mediated signaling pathway

Disease: Blood Group, Cromer System
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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