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anti-Dnmt3a antibody :: Rabbit anti-Human, Rat Dnmt3a Monoclonal Antibody

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Catalog # MBS8533873
Unit / Price
  0.1 mL  /  $290 +1 FREE 8GB USB
anti-Dnmt3a antibody
Product Name

Dnmt3a, Monoclonal Antibody

Also Known As

Dnmt3a

Product Synonym Names
DNA (cytosine-5)-methyltransferase 3A; DNA methyltransferase HsaIIIA
Product Synonym Gene Name
Dnmt3a; DNA MTase HsaIIIA; M.HsaIIIA; DNMT3A[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
166
OMIM
602769
3D Structure
ModBase 3D Structure for Q9Y6K1
Clonality
Monoclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Purity/Purification
ProA affinity purified
Immunogen
Recombinant Protein
Storage Buffer
1*TBS (pH7.4), 1% BSA, 40% Glycerol.
Preservative
0.05% Sodium Azide.
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-Dnmt3a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-Dnmt3a antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
NCBI/Uniprot data below describe general gene information for Dnmt3a. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,866 Da
NCBI Official Full Name
DNA (cytosine-5)-methyltransferase 3A isoform c
NCBI Official Synonym Full Names
DNA methyltransferase 3 alpha
NCBI Official Symbol
DNMT3A  [Similar Products]
NCBI Official Synonym Symbols
TBRS; DNMT3A2; M.HsaIIIA
  [Similar Products]
NCBI Protein Information
DNA (cytosine-5)-methyltransferase 3A
UniProt Protein Name
DNA (cytosine-5)-methyltransferase 3A
UniProt Synonym Protein Names
DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIA
Protein Family
UniProt Gene Name
DNMT3A  [Similar Products]
UniProt Synonym Gene Names
Dnmt3a; DNA MTase HsaIIIA; M.HsaIIIA  [Similar Products]
NCBI Summary for Dnmt3a
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]
UniProt Comments for Dnmt3a
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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