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anti-KRT10 antibody :: Mouse Keratin K10 Monoclonal Antibody

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Catalog # MBS531604
Unit / Price
  1 mL  /  $490 +1 FREE 8GB USB
anti-KRT10 antibody
Product Name

Keratin K10 (KRT10), Monoclonal Antibody

Also Known As

Keratin K10 antibody

Product Synonym Names
Monoclonal Keratin K10; Anti-Keratin K10; Keratin K 10; Keratin K-10; Keratin K10; Cytokeratin 10
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
584
OMIM
113800
3D Structure
ModBase 3D Structure for P13645
Clonality
Monoclonal
Isotype
IgG1
Clone Number
DE-K10
Host
Mouse
Species Reactivity
Human keratin K10
Purity/Purification
Culture supernatant
Form/Format
Suppleid as culture supernatant diluted in 0.15 M PBS with 1% BSA and 0.1% NaN3
Biological Significance
Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
Keratin K10 antibody was raised in mouse using cytoskeletal preparation from human epidermis as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-KRT10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KRT10 antibody
Mouse monoclonal Keratin K10 antibody
Product Categories/Family for anti-KRT10 antibody
Applications Tested/Suitable for anti-KRT10 antibody
Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)
Application Notes for anti-KRT10 antibody
IHC-F: 1:5-1:10
IHC-P: 1:5-1:10
NCBI/Uniprot data below describe general gene information for KRT10. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,827 Da[Similar Products]
NCBI Official Full Name
keratin, type I cytoskeletal 10
NCBI Official Synonym Full Names
keratin 10, type I
NCBI Official Symbol
KRT10  [Similar Products]
NCBI Official Synonym Symbols
BIE; EHK; K10; KPP; BCIE; CK10
  [Similar Products]
NCBI Protein Information
keratin, type I cytoskeletal 10
UniProt Protein Name
Keratin, type I cytoskeletal 10
UniProt Synonym Protein Names
Cytokeratin-10; CK-10; Keratin-10; K10
Protein Family
UniProt Gene Name
KRT10  [Similar Products]
UniProt Synonym Gene Names
KPP; CK-10; K10  [Similar Products]
UniProt Entry Name
K1C10_HUMAN
NCBI Summary for KRT10
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
UniProt Comments for KRT10
K10: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K1.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: extracellular space; membrane; keratin filament; cytoplasm; intermediate filament; nucleus

Molecular Function: structural constituent of epidermis

Biological Process: keratinocyte differentiation

Disease: Erythroderma, Ichthyosiform, Congenital Reticular; Epidermolytic Hyperkeratosis; Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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