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anti-ICOS antibody :: Rat anti-Mouse ICOS Monoclonal Antibody

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Catalog # MBS378147
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anti-ICOS antibody
Product Name

ICOS, Monoclonal Antibody

Popular Item
Also Known As

ICOS

Product Synonym Names
AILIM; CCLP; CRP-1; H4; Ly115
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
199
OMIM
AJ277832 mRNA
3D Structure
ModBase 3D Structure for Q9Y6W8
Clonality
Monoclonal
Isotype
IgG2b Kappa
Clone Number
7E.17G9
Host
Rat
Species Reactivity
Mouse
Purity/Purification
>95%
Form/Format
PBS, pH7
Concentration
2mg/ml (lot specific)
Preservative
None
Total Protein
500ug
Endotoxin
<2EU/mg
Sterile
0.2um filtration
Preparation and Storage
Store at -20 degree C. For long term storage, aliquot and store frozen. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-ICOS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ICOS antibody
Activation, Flow Cytometry (FC/FACS)
NCBI/Uniprot data below describe general gene information for ICOS. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
inducible T-cell costimulator
NCBI Official Synonym Full Names
inducible T-cell costimulator
NCBI Official Symbol
NCBI Official Synonym Symbols
AILIM; CD278; CVID1
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NCBI Protein Information
inducible T-cell costimulator
UniProt Protein Name
Inducible T-cell costimulator
UniProt Synonym Protein Names
Activation-inducible lymphocyte immunomediatory molecule; CD_antigen: CD278
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
AILIM  [Similar Products]
NCBI Summary for ICOS
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]
UniProt Comments for ICOS
ICOS: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1). CVID1 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be lo. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q33.2

Cellular Component: plasma membrane

Molecular Function: phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Biological Process: phosphoinositide-mediated signaling; regulation of phosphoinositide 3-kinase cascade; T cell costimulation

Disease: Immunodeficiency, Common Variable, 1; Immunodeficiency, Common Variable, 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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