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anti-PLAUR antibody :: Rat anti-Mouse Urokinase Plasminogen Activator Receptor Monoclonal Antibody

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Catalog # MBS632008
Unit / Price
  100 Tests  /  $670 +1 FREE 8GB USB
Testing Data
Product Name

Urokinase Plasminogen Activator Receptor (PLAUR), Monoclonal Antibody

Popular Item
Also Known As

Urokinase Plasminogen Activator Receptor (U Plasminogen Activator Receptor, UPA Receptor, uPAR, U-PAR, CD87, CD87 Antigen, MO3, Monocyte Activation Antigen Mo3, Plasminogen Activator Urokinase Receptor, PLAUR, URKR) (PE)

Product Synonym Names
Anti -Urokinase Plasminogen Activator Receptor (U Plasminogen Activator Receptor, UPA Receptor, uPAR, U-PAR, CD87, CD87 Antigen, MO3, Monocyte Activation Antigen Mo3, Plasminogen Activator Urokinase Receptor, PLAUR, URKR) (PE)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 19; NC_000019.9 (44150248..44174502, complement). Location: 19q13
3D Structure
ModBase 3D Structure for Q03405
Clone Number
Species Reactivity
Recognizes mouse uPAR. No crossreactvity with recombinant human uPAR in Western Blot.
Purified by Protein G affinity chromatography.
Supplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).
0.025 mg/ml (lot specific)
Recombinant protein corresponding to Leu24-Thr297 from mouse uPAR expressed in NS0 cells. UniProt Accession: P35456.
Fusion of a mouse myeloma with B cells obtained from a rat immunized with purified, NS0-derived, recombinant mouse uPAR
Preparation and Storage
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Other Notes
Small volumes of anti-PLAUR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PLAUR antibody
CD87, a 45- to 60kD protein, consists of three structurally homologous domains of ~90aa, designated D1, D2, and D3, each containing a conserved arrangement of disulfide bonds and separated by short interdomain linker sequences. uPAR exists in various molecular forms; heavily glycosylated, a cleaved form, a soluble form and spliced forms. CD87 is expressed by monocytes/macrophages, neutrophils, endothelial, smooth muscle cells and epithelial cells. CD87 is overexpressed upon exposure to inflammatory mediators. The protein is also highly expressed by tumor cells and contributes to their invasiveness and metastatic potential. CD87 is a multiligand receptor that operates as a key element in pathophysiological processes involving cell migration and tissue remodelling during inflammation and cancer metastasis. CD87 binds with high affinity the Ser-proteinase urokinase-type plasminogen activator (uPA) which, upon binding catalyzes the conversion of plasminogen into plasmin which activates various matrix metalloproteinase leading to a high potential for pericellular proteolysis. CD87 functions also as an adhesion molecule by binding vitronectin, thus contributing to leukocytic adherence. High-affinity binding of CD87 to both uPA and vitronectin requires the presence of domain 1 (D1). Yet, CD87 participates in cell adherence and migration also through two other routes, a physical association and functional interaction with various integrins and via an intrinsic chemotactic activity associated to the D1-D2 linker sequence.
Applications Tested/Suitable for anti-PLAUR antibody
Western Blot and Flow Cytometry
Other applications not tested.
Application Notes for anti-PLAUR antibody
Flow Cytometry: 10ul/10e6 cells using mouse whole blood monocytes
Optimal dilutions to be determined by the researcher.

Testing Data of anti-PLAUR antibody
Mouse whole blood monocytes were stained with MBS632008 (filled histogram) or isotype control antibody
anti-PLAUR antibody Testing Data image
NCBI/Uniprot data below describe general gene information for PLAUR. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,978 Da[Similar Products]
NCBI Official Full Name
urokinase plasminogen activator receptor
NCBI Official Synonym Full Names
plasminogen activator, urokinase receptor
NCBI Official Symbol
PLAUR  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
urokinase plasminogen activator surface receptor; monocyte activation antigen Mo3; u-plasminogen activator receptor form 2
UniProt Protein Name
Urokinase plasminogen activator surface receptor
UniProt Synonym Protein Names
Monocyte activation antigen Mo3
UniProt Gene Name
PLAUR  [Similar Products]
UniProt Synonym Gene Names
MO3; UPAR  [Similar Products]
UniProt Entry Name
NCBI Summary for PLAUR
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq]
UniProt Comments for PLAUR
uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: endoplasmic reticulum membrane; extrinsic to membrane; focal adhesion; endoplasmic reticulum lumen; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein domain specific binding; protein binding; U-plasminogen activator receptor activity; enzyme binding; receptor activity; receptor binding

Biological Process: fibrinolysis; cellular protein metabolic process; attachment of GPI anchor to protein; regulation of proteolysis; C-terminal protein lipidation; blood coagulation; post-translational protein modification; signal transduction; chemotaxis; cell motility
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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