Q9UPA5
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Bassoon protein
NCBI Official Synonym Full Names
bassoon (presynaptic cytomatrix protein)
NCBI Official Synonym Symbols
NCBI Protein Information
protein bassoon; zinc finger protein 231; neuronal double zinc finger protein
UniProt Protein Name
Protein bassoon
UniProt Synonym Protein Names
Zinc finger protein 231
UniProt Synonym Gene Names
UniProt Entry Name
BSN_HUMAN
NCBI Summary for BSN
Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq]
UniProt Comments for BSN
BSN: involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses. Interacts with CAST1, RIMS1 and UNC13A. Part of a complex consisting of ERC2, RIMS1 and BSN. Localized to the active zone of presynaptic density. Mice lacking functional BSN showed a reduced excitability attributed to inactivation of a fraction of brain glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers, but are unable to fuse. In retina, mutants lacking functional BSN showed normal retinal anatomy, but synapses lacked anchoring of the photoreceptor ribbon to the presynaptic active zone resulting in impaired photoreceptor synaptic transmission. Two alternatively spliced isoforms have been reported.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: axon; postsynaptic density; dendrite; presynaptic active zone; excitatory synapse; cell junction; nucleus
Molecular Function: metal ion binding
Biological Process: synaptic transmission
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Products associated with anti-BSN antibody
Diseases associated with anti-BSN antibody
Organs/Tissues associated with anti-BSN antibody
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