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anti-CD81 antibody :: Hamster anti-Mouse, rat CD81 Monoclonal Antibody

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Catalog # MBS520207
Unit / Price
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  0.25 mg  /  $275 +1 FREE 8GB USB
Testing Data
Product Name

CD81, Monoclonal Antibody

Full Product Name

Anti-Mouse/Rat CD81, Purified (Clone Eat2) (mouse IgG1)

Product Synonym Names
CD81, Purified (Clone Eat2) (mouse IgG1); Purified Anti-Mouse CD81 (TAPA-1) Monoclonal Antibody
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 11; NC_000011.9 (2397391..2418649). Location: 11p15.5
OMIM
186845
3D Structure
ModBase 3D Structure for P60033
Clonality
Monoclonal
Isotype
Hamster IgG
Clone Number
EAT 2
Host
Hamster
Species Reactivity
Mouse, rat
Specificity
CD81 (TAPA-1) (Mouse CD81 (TAPA-1))
Form/Format
Purified (Purified Ig buffered in PBS and 0.02% NaN3 (purified from cell culture supernatant via Protein G Chromatography))
Concentration
Antibody Concentration: 1.0 mg/ml (lot specific)
Presentation
250 ug purified Ig buffered in PBS and 0.02% NaN3
Preparation and Storage
Store at 4 degree C. For long term storage, aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-CD81 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD81 antibody
MBS520207 reacts with the extracellular loops of murine CD81 (TAPA- 1) molecule. As a member of the tetraspanin superfamily of cell-surface proteins, CD81 has been linked to the control of cell proliferation, adhesion and motility. CD81 is expressed in higher levels on resting murine B cells than on resting T cells and is functionally active on B cells as it induces homotypic adhesion of B lymphocytes. Unlike human CD81, which is expressed equally on all thymocytes, murine CD81 is upregulated on CD4+CD8+ thymocytes, then down-regulated again on mature single-positive thymocytes. Murine dendritic cells, splenic macrophages and non-killer cells all express very high levels of CD81. CD81 has also been involved in the induction of IL-4 secretion from T cells during Th2 immune responses. It has been reported that CD81 expression can also be induced in mature T cells upon activation. This anti-CD81 mAb has been shown to decrease the proliferation of LPS stimulated CD81+/+ B cells to levels similar to that of CD81-/ - B cells.
Applications Tested/Suitable for anti-CD81 antibody
Immunohistochemistry (IHC)

Testing Data of anti-CD81 antibody
anti-CD81 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for CD81. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,809 Da
NCBI Official Full Name
CD81 antigen
NCBI Official Synonym Full Names
CD81 molecule
NCBI Official Symbol
NCBI Official Synonym Symbols
S5.7; CVID6; TAPA1; TSPAN28
  [Similar Products]
NCBI Protein Information
CD81 antigen; tspan-28; tetraspanin-28; 26 kDa cell surface protein TAPA-1; CD81 antigen (target of antiproliferative antibody 1)
UniProt Protein Name
CD81 antigen
UniProt Synonym Protein Names
26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
TAPA1; TSPAN28; Tspan-28  [Similar Products]
UniProt Entry Name
CD81_HUMAN
NCBI Summary for CD81
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. [provided by RefSeq, Jul 2008]
UniProt Comments for CD81
Function: May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.

Subunit structure: Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. Interacts directly with IGSF8. Interacts with CD53 and SCIMP. Interacts with IFITM1, IFITM2 and IFITM3. Part of a GPCR-tetraspanin complex consisting at least of GPR56, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of GPR56 with GNA11. Ref.6 Ref.8 Ref.9 Ref.10 Ref.11 Ref.14

Subcellular location: Membrane; Multi-pass membrane protein.

Tissue specificity: Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.

Post-translational modification: Not glycosylated

Probable.

Involvement in disease: Immunodeficiency, common variable, 6 (CVID6) [MIM:613496]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12

Sequence similarities: Belongs to the tetraspanin (TM4SF) family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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