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anti-GAD65 antibody :: Mouse anti-Mouse, Rat GAD65 Monoclonal Antibody

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Catalog # MBS531226
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anti-GAD65 antibody
Product Name

GAD65, Monoclonal Antibody

Popular Item
Full Product Name

GAD65 antibody

Product Synonym Names
Monoclonal GAD65; Anti-GAD65; GAD 65; Glutamic Acid Decarboxylase 65; GAD65; GAD-65
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
138275
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
9A6
Host
Mouse
Species Reactivity
Mouse, Rat
Specificity
Human
Form/Format
PBS with 50% glycerol, pH 7.2.
Concentration
1.0 mg/ml (lot specific)
Biological Significance
Glutamic acid decarboxylase (GAD) catalyzes formation of ?-Aminobutyric acid (GABA), which is an inhibitory neurotransmitter, and is present in brain as well as several tissues outside the central nervous system. Biological functions of GAD and GABA extend beyond regulation of neurotransmission to include effects on the immune system as well as modulation of cell proliferation, protein synthesis, and metabolism.
Immunogen
GAD65 antibody was raised in mouse using recombinant GST-human brain GAD65 fusion protein as the immunogen.
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
Other Notes
Small volumes of anti-GAD65 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GAD65 antibody
Mouse monoclonal GAD65 antibody
Applications Tested/Suitable for anti-GAD65 antibody
Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-GAD65 antibody
IHC: 1-10 ug/ml
WB: 1 ug/ml
NCBI/Uniprot data below describe general gene information for GAD65. It may not necessarily be applicable to this product.
NCBI GI #
NCBI Accession #
UniProt Secondary Accession #
Molecular Weight
65,411 Da
NCBI Official Full Name
glutamic acid decarboxylase, partial
UniProt Protein Name
Glutamate decarboxylase 2
UniProt Synonym Protein Names
65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform
UniProt Gene Name
UniProt Synonym Gene Names
GAD65; GAD-65  [Similar Products]
UniProt Entry Name
DCE2_HUMAN
UniProt Comments for GAD65
GAD2: Catalyzes the production of GABA. Homodimer. Belongs to the group II decarboxylase family.

Protein type: Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - taurine and hypotaurine; Lyase; EC 4.1.1.15; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - alanine, aspartate and glutamate

Chromosomal Location of Human Ortholog: 10p11.23

Cellular Component: presynaptic membrane; Golgi membrane; synaptic vesicle membrane; perinuclear region of cytoplasm; axon; plasma membrane; cytosol; cell junction

Molecular Function: protein binding; glutamate binding; glutamate decarboxylase activity; protein heterodimerization activity; pyridoxal phosphate binding

Biological Process: response to drug; synaptic transmission; glutamate decarboxylation to succinate; neurotransmitter secretion; neurotransmitter biosynthetic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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