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anti-Cacng2 antibody :: Mouse anti-Rat, Mouse TARP Gamma2 Monoclonal Antibody

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Catalog # MBS802776
Unit / Price
  0.1 mg  /  $390 +1 FREE 8GB USB
Western Blot (WB)
Product Name

TARP Gamma2 (Cacng2), Monoclonal Antibody

Popular Item
Also Known As

Anti-TARP Gamma2/Stargazin Antibody: Clone S245-1

Product Synonym Names
CACNG2; Calcium channel voltage dependent gamma subunit 2; CaV gamma 2; Ipr328; MGC123981; MGC138502; MGC138504; Voltage-dependent calcium channel gamma-2 subunit; Neuronal voltage-gated calcium channel gamma-2 subunit; Stargazin; Stg; Stargazer; TARP
Matching Pairs
Matching Pairs
Unconjugated Antibody: TARP Gamma2 Clone #S245-1 (MBS802776)
Alkaline Phosphatase Conjugated Antibody: TARP Gamma2 Clone #S245-1 (MBS800592)
Matching Pairs
Unconjugated Antibody: TARP Gamma2 Clone #S245-1 (MBS802776)
ATTO 680 Conjugated Antibody: TARP Gamma2 Clone #S245-1 (MBS800771)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
323
3D Structure
ModBase 3D Structure for Q71RJ2
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
S245-1
Host
Mouse
Species Reactivity
Rat, Mouse
Form/Format
Protein G Purified
Concentration
1mg/mL (lot specific)
Certificate of Analysis
1 ug/mL was sufficient for detection of TARP Gamma2/ Stargazin in 20ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody
Immunogen
Fusion protein amino acids 203-323 (Cytoplasmic C-terminus) of rat TARPGamma2
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Research Area(s)
Neuroscience
Ion Channels
Calcium Channels
Voltage-Gated Calcium Channels
Cell Structure
Post-Synaptic Markers
Cellular Localization
Membrane
Gene ID
84347
Acession Number
NP_445803.1
Swiss Prot
Q71Rj2
Preparation and Storage
-20 degree C/ 1 yr + Avoid freeze/thaw cycle.
Shipping: Cold Packs/ 4 degree C.
Other Notes
Small volumes of anti-Cacng2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Cacng2 antibody
Background Info: Detects ~36kDa. Does not cross-react with TARPGamma3, TARPGamma4 and TARPGamma8

Scientific Background: Stargazin belongs to a group called voltage gated calcium channels (VGCCs) which are present in most excitable cells. Stargazin is thought to stabilize the calcium channel in an inactivated (closed) state. There are five high voltage activated calcium channel types (L, N, P, Q, and R) and one low voltage activated channel type (T). Each of these channels exists as a heteromultimer of a1, b, a2/ d and g subunits with the voltage activated calcium channel function carried by the a subunits. VGCCs exert spatial and temporal control over cellular calcium concentrations and serve to modulate neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression, and neuronal survival.
Product Categories/Family for anti-Cacng2 antibody
Applications Tested/Suitable for anti-Cacng2 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-Cacng2 antibody
WB: (1:1000); Optimal dilutions for assays should be determined by the user.

Western Blot (WB) of anti-Cacng2 antibody
Western Blot analysis of Rat brain lysates showing detection of Stargazin Calcium Channel protein using Mouse Anti-Stargazin Calcium Channel Monoclonal Antibody, Clone S245-1. Primary Antibody: Mouse Anti-Stargazin Calcium Channel Monoclonal Antibody at 1:100, 1:250, 1:500, and 1:1000.
anti-Cacng2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for Cacng2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
voltage-dependent calcium channel gamma-2 subunit
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, gamma subunit 2
NCBI Official Symbol
Cacng2  [Similar Products]
NCBI Official Synonym Symbols
Ipr328
  [Similar Products]
NCBI Protein Information
voltage-dependent calcium channel gamma-2 subunit; TARP gamma-2; transmembrane AMPAR regulatory protein gamma-2; neuronal voltage-gated calcium channel gamma-2 subunit
UniProt Protein Name
Voltage-dependent calcium channel gamma-2 subunit
UniProt Synonym Protein Names
Neuronal voltage-gated calcium channel gamma-2 subunit; Transmembrane AMPAR regulatory protein gamma-2; TARP gamma-2
UniProt Gene Name
Cacng2  [Similar Products]
UniProt Synonym Gene Names
TARP gamma-2  [Similar Products]
UniProt Entry Name
CCG2_RAT
NCBI Summary for Cacng2
subunit of voltage-dependent calcium channel; involved in influencing channel properties [RGD, Feb 2006]
UniProt Comments for Cacng2
Stargazin: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with GRIA1. Brain. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium

Cellular Component: voltage-gated calcium channel complex

Molecular Function: voltage-gated calcium channel activity; ionotropic glutamate receptor binding; protein binding; calcium channel regulator activity

Biological Process: membrane depolarization; regulation of membrane potential; membrane hyperpolarization; transmission of nerve impulse; neuromuscular junction development; neurological system process
Product References and Citations for anti-Cacng2 antibody
1. Gill M.B., et al. (2011) J Neurosci. 31(18): 6928-6938. 2. Yu L. (2011) Neuroscience. 178: 13-20. 3. Steinmetz C.C., Turrigiano G.G. (2010) J Neurosci. 30: 14685-14690. 4. Kato. A.S. et al. (2007) J Neurosci. 27: 4969-4977. 5. Letts V.A., et al. (1998) Nat Genet. 19: 340-34

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Organs/Tissues associated with anti-Cacng2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >88 publications with Cacng2 and Brain
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