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anti-CD28 antibody :: Hamster anti-Murine CD28 Monoclonal Antibody

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Catalog # MBS531972
Unit / Price
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  0.1 mg  /  $315 +1 FREE 8GB USB
  0.2 mg  /  $500 +1 FREE 8GB USB
anti-CD28 antibody
Product Name

CD28, Monoclonal Antibody

Popular Item
Full Product Name

CD28 antibody (PE)

Product Synonym Names
Monoclonal CD28; Anti-CD28; CD 28; CD28; CD-28
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P31041
Clonality
Monoclonal
Isotype
IgG
Clone Number
37.51
Host
Hamster
Species Reactivity
Murine
Form/Format
Supplied as a liquid in PBS, with NaN3 added as preservative.
Concentration
0.1 mg/ml (lot specific)
Biological Significance
CD28 (Cluster of Differentiation 28) is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for B7.1 (CD80) and B7.2 (CD86). When activated by Toll-like receptor ligands, the B7.1 expression is upregulated in antigen presenting cells (APCs). The B7.2 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Tag/Conjugate
PE
Immunogen
CD28 antibody (PE) was raised in hamster using CD28 costimulatory receptor as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-CD28 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD28 antibody
Hamster monoclonal CD28 antibody (PE)
Applications Tested/Suitable for anti-CD28 antibody
Flow Cytometry (FC/FACS)
NCBI/Uniprot data below describe general gene information for CD28. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,243 Da
NCBI Official Full Name
CD28, partial
NCBI Official Synonym Full Names
CD28 antigen
NCBI Official Symbol
NCBI Protein Information
T-cell-specific surface glycoprotein CD28
UniProt Protein Name
T-cell-specific surface glycoprotein CD28
UniProt Synonym Protein Names
CD_antigen: CD28
UniProt Gene Name
UniProt Entry Name
CD28_MOUSE
UniProt Comments for CD28
CD28: a type I plasma membrane protein Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Binds to B7-1 and -2. Expressed in T cells and plasma cells, but not in less mature B cells. Six splice-variant isoforms have been described.

Protein type: Cell surface; Membrane protein, integral

Cellular Component: membrane; integral to membrane; plasma membrane; immunological synapse; lipid raft; external side of plasma membrane

Molecular Function: protein homodimerization activity; protease binding; SH3/SH2 adaptor activity

Biological Process: positive regulation of isotype switching to IgG isotypes; T cell activation; positive regulation of mitosis; positive regulation of interleukin-2 biosynthetic process; negative thymic T cell selection; T cell receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of inflammatory response to antigenic stimulus; positive regulation of protein kinase B signaling cascade; T cell costimulation; positive regulation of T cell proliferation; immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulatory T cell differentiation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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