AAA37396.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,243 Da
NCBI Official Full Name
CD28, partial
NCBI Official Synonym Full Names
CD28 antigen
NCBI Protein Information
T-cell-specific surface glycoprotein CD28
UniProt Protein Name
T-cell-specific surface glycoprotein CD28
UniProt Synonym Protein Names
CD_antigen: CD28
UniProt Entry Name
CD28_MOUSE
UniProt Comments for CD28
CD28: a type I plasma membrane protein Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Binds to B7-1 and -2. Expressed in T cells and plasma cells, but not in less mature B cells. Six splice-variant isoforms have been described.
Protein type: Cell surface; Membrane protein, integral
Cellular Component: membrane; integral to membrane; plasma membrane; immunological synapse; lipid raft; external side of plasma membrane
Molecular Function: protein homodimerization activity; SH3/SH2 adaptor activity; protease binding
Biological Process: positive regulation of isotype switching to IgG isotypes; T cell activation; positive regulation of mitosis; positive regulation of interleukin-2 biosynthetic process; negative thymic T cell selection; T cell receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of inflammatory response to antigenic stimulus; T cell costimulation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of alpha-beta T cell proliferation; immune response; positive regulation of T cell proliferation; regulatory T cell differentiation
Research Articles on CD28
Precautions
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Disclaimer
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Products associated with anti-CD28 antibody
Pathways associated with anti-CD28 antibody
Diseases associated with anti-CD28 antibody
Organs/Tissues associated with anti-CD28 antibody
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