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anti-CD44 antibody :: Rat anti-Murine CD44 CD44 Monoclonal Antibody

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Catalog # MBS531967
Unit / Price
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  0.1 mg  /  $360 +1 FREE 8GB USB
anti-CD44 antibody
Product Name

CD44, Monoclonal Antibody

Full Product Name

CD44 antibody (Spectral Red)

Product Synonym Names
Monoclonal CD44; Anti-CD44; H-CAM; CD 44; CD-44; CD44; HCAM; Cluster of differentiation 44; Pgp1; MGC10468; MDU2; phagocytic glycoprotein 1; MDU3; MIC4; CSPG8; LHR; CD44 antigen; Hermes antigen; IN
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O08779
Clonality
Monoclonal
Isotype
IgG1
Clone Number
KM201
Host
Rat
Species Reactivity
Murine CD44
Form/Format
Supplied as a liquid in PBS, with NaN3 added as preservative.
Concentration
0.1 mg/ml (lot specific)
Biological Significance
The CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded by the CD44 gene.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Tag/Conjugate
Spectral Red
Immunogen
CD44 antibody (Spectral Red) was raised in rat using murine CD44 as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-CD44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD44 antibody
Rat monoclonal CD44 antibody (Spectral Red)
Applications Tested/Suitable for anti-CD44 antibody
Flow Cytometry (FC/FACS)
NCBI/Uniprot data below describe general gene information for CD44. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
85,918 Da
NCBI Official Full Name
CD44 antigen
NCBI Official Synonym Full Names
CD44 molecule (Indian blood group)
NCBI Official Symbol
NCBI Official Synonym Symbols
CD44A; METAA; RHAMM
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NCBI Protein Information
CD44 antigen
UniProt Protein Name
CD44 protein
UniProt Synonym Protein Names
CD44 protein
Protein Family
UniProt Gene Name
UniProt Entry Name
O08779_RAT
NCBI Summary for CD44
adhesion molecule involved in migration, cell fusion and resportion in osteoclasts that also plays a role in cellular metastasis [RGD, Feb 2006]
UniProt Comments for CD44
CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis; Cell adhesion

Cellular Component: Golgi apparatus; cell surface; protein complex; focal adhesion; basolateral plasma membrane; cytoplasm; apical plasma membrane; plasma membrane; integral to membrane; nucleus; external side of plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; transmembrane receptor activity; cytokine binding; hyaluronic acid binding; phosphoprotein binding; protein kinase binding; hyalurononglucosaminidase activity; epidermal growth factor receptor binding

Biological Process: cell migration; positive regulation of heterotypic cell-cell adhesion; Wnt receptor signaling pathway; positive regulation of neutrophil apoptosis; negative regulation of caspase activity; response to organic cyclic substance; positive regulation of peptidyl-serine phosphorylation; blood vessel maturation; response to vitamin A; hyaluronan catabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of mature B cell apoptosis; ureteric bud branching; cartilage development; regulation of cell growth; inflammatory response; cell adhesion; healing during inflammatory response; neurite development; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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