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anti-CD86 antibody :: Rat anti-Murine CD86 CD86 Monoclonal Antibody

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Catalog # MBS531955
Unit / Price
  0.5 mg  /  $515 +1 FREE 8GB USB
anti-CD86 antibody
Product Name

CD86, Monoclonal Antibody

Also Known As

CD86 antibody (Azide Free)

Product Synonym Names
Monoclonal CD86; Anti-CD86; CD-86; CD 86; CD86; B72
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
323
OMIM
601020
3D Structure
ModBase 3D Structure for P42081
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
GL1
Host
Rat
Species Reactivity
Murine CD86
Form/Format
Supplied as a liquid in PBS.
Concentration
0.5 mg/ml (lot specific)
Biological Significance
Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.
Immunogen
CD86 antibody (Azide free) was raised in rat using LPS-activated murine B cells as the immunogen.
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles
Other Notes
Small volumes of anti-CD86 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD86 antibody
Rat monoclonal CD86 antibody (Azide Free)
Product Categories/Family for anti-CD86 antibody
Applications Tested/Suitable for anti-CD86 antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for CD86. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,420 Da
NCBI Official Full Name
CD86, partial
NCBI Official Synonym Full Names
CD86 molecule
NCBI Official Symbol
NCBI Official Synonym Symbols
B70; B7-2; B7.2; LAB72; CD28LG2
  [Similar Products]
NCBI Protein Information
T-lymphocyte activation antigen CD86
UniProt Protein Name
T-lymphocyte activation antigen CD86
UniProt Synonym Protein Names
Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD_antigen: CD86
UniProt Gene Name
UniProt Synonym Gene Names
CD28LG2  [Similar Products]
UniProt Entry Name
CD86_HUMAN
NCBI Summary for CD86
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
UniProt Comments for CD86
CD86: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: cell surface; intracellular membrane-bound organelle; plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; coreceptor activity; receptor activity; receptor binding

Biological Process: positive regulation of lymphotoxin A biosynthetic process; nerve growth factor receptor signaling pathway; T cell activation; negative regulation of T cell anergy; viral reproduction; positive regulation of interleukin-2 biosynthetic process; positive regulation of transcription, DNA-dependent; myeloid dendritic cell differentiation; positive regulation of activated T cell proliferation; positive regulation of interleukin-4 biosynthetic process; positive regulation of T-helper 2 cell differentiation; cell-cell signaling; T cell proliferation during immune response; positive regulation of cell proliferation; response to yeast; defense response to virus; aging; response to drug; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; B cell activation; T cell costimulation; toll-like receptor signaling pathway; innate immune response; immune response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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