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anti-VEGF antibody :: Mouse anti-Rabbit VEGF Monoclonal Antibody

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Catalog # MBS530756
Unit / Price
  0.2 mg  /  $780 +1 FREE 8GB USB
anti-VEGF antibody
Product Name

VEGF, Monoclonal Antibody

Also Known As

VEGF antibody (BSA/Azide Free)

Product Synonym Names
Monoclonal VEGF; Anti-VEGF; Vascular Endothelial Growth Factor; VPF; VEGF; Anti VEGF; Glioma-derived endothelial cell mitogen; Folliculostellate cell-derived growth factor
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
191
OMIM
192240
3D Structure
ModBase 3D Structure for P15692
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
JH121
Host
Mouse
Species Reactivity
Rabbit
Specificity
Human
Purity/Purification
VEGF antibody (BSA/Azide Free) was purified by Protein G chromatography.
Form/Format
Antibody purified from ascites and supplied in 10mM PBS, pH 7.4
Concentration
1.0 mg/ml (lot specific)
Biological Significance
VEGF (vascular endothelial growth factor) is a homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. It exhibits potent mitogenic and permeability inducing properties specific for the vascular endothelium. Of the four isoforms of VEGF, the smaller two, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two (VEGF189 and VEGF206) remain cell associated.
Immunogen
VEGF antibody (BSA/Azide Free) was raised in mouse using recombinant human VEGF121 as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-VEGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-VEGF antibody
Mouse monoclonal VEGF antibody (BSA/Azide Free)
Product Categories/Family for anti-VEGF antibody
Applications Tested/Suitable for anti-VEGF antibody
Neutralization
NCBI/Uniprot data below describe general gene information for VEGF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19-22 kDa (predicted detection band MW)
NCBI Official Full Name
vascular endothelial growth factor
NCBI Official Synonym Full Names
vascular endothelial growth factor A
NCBI Official Symbol
VEGFA  [Similar Products]
NCBI Official Synonym Symbols
VPF; VEGF; MVCD1
  [Similar Products]
NCBI Protein Information
vascular endothelial growth factor A
UniProt Protein Name
Vascular endothelial growth factor A
UniProt Synonym Protein Names
Vascular permeability factor; VPF
UniProt Gene Name
VEGFA  [Similar Products]
UniProt Synonym Gene Names
VEGF; VEGF-A; VPF  [Similar Products]
UniProt Entry Name
VEGFA_HUMAN
NCBI Summary for VEGF
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for VEGF
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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