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anti-IL6 antibody :: Mouse anti-Sheep Interleukin 6 (IL6) Monoclonal Antibody

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Catalog # MBS2090749
Unit / Price
  0.01 mg  /  $115 +1 FREE 8GB USB
  0.02 mg  /  $130 +1 FREE 8GB USB
  0.05 mg  /  $170 +1 FREE 8GB USB
  0.1 mg  /  $220 +1 FREE 8GB USB
  0.2 mg  /  $285 +1 FREE 8GB USB
  1 mg  /  $675 +1 FREE 8GB USB
anti-IL6 antibody
Product Name

Interleukin 6 (IL6), Monoclonal Antibody

Full Product Name

Biotin-Linked Monoclonal Antibody to Interleukin 6 (IL6)

Product Gene Name
Matching Pairs
Unconjugated Antibody: Interleukin 6 (IL6) (MBS2012740)
Biotin Conjugated Antibody: Interleukin 6 (IL6) (MBS2090749)
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
X04430 mRNA
3D Structure
ModBase 3D Structure for P05231
Clonality
Monoclonal
Host
Mouse
Species Reactivity
Sheep
Concentration
500ug/ml (lot specific)
Conjugation
Biotin
Immunogen
Gly30~Lys208
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-IL6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-IL6 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for IL6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,718 Da
NCBI Official Full Name
interleukin-6 isoform 1
NCBI Official Synonym Full Names
interleukin 6
NCBI Official Symbol
NCBI Official Synonym Symbols
CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
  [Similar Products]
NCBI Protein Information
interleukin-6
UniProt Protein Name
Interleukin-6
UniProt Synonym Protein Names
B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
IFNB2; IL-6; BSF-2; CDF; IFN-beta-2  [Similar Products]
NCBI Summary for IL6
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for IL6
IL6: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ). An inflammatory articular disorder with systemic- onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. Belongs to the IL-6 superfamily.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p15.3

Cellular Component: endoplasmic reticulum lumen; external side of plasma membrane; extracellular region; extracellular space; interleukin-6 receptor complex

Molecular Function: cytokine activity; growth factor activity; interleukin-6 receptor binding; protein binding

Biological Process: acute-phase response; aging; bone remodeling; cell growth; cell redox homeostasis; cellular protein metabolic process; cellular response to nutrient levels; cytokine-mediated signaling pathway; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; defense response to protozoan; defense response to virus; endocrine pancreas development; glucose homeostasis; hepatic immune response; humoral immune response; inflammatory response; lymphocyte costimulation; monocyte chemotaxis; muscle maintenance; negative regulation of apoptosis; negative regulation of bone resorption; negative regulation of cell proliferation; negative regulation of chemokine biosynthetic process; negative regulation of collagen biosynthetic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of cytokine secretion; negative regulation of fat cell differentiation; negative regulation of gluconeogenesis; negative regulation of hormone secretion; negative regulation of membrane potential; negative regulation of muscle organ development; negative regulation of protein kinase activity; neuron projection development; neutrophil apoptosis; neutrophil mediated immunity; platelet activation; positive regulation of acute inflammatory response; positive regulation of apoptosis; positive regulation of B cell activation; positive regulation of cell proliferation; positive regulation of chemokine production; positive regulation of DNA replication; positive regulation of epithelial cell proliferation; positive regulation of immunoglobulin secretion; positive regulation of interleukin-6 production; positive regulation of JAK-STAT cascade; positive regulation of leukocyte chemotaxis; positive regulation of MAPK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of osteoblast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein import into nucleus, translocation; positive regulation of protein kinase B signaling; positive regulation of smooth muscle cell proliferation; positive regulation of T cell proliferation; positive regulation of T-helper 2 cell differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of translation; positive regulation of transmission of nerve impulse; positive regulation of tyrosine phosphorylation of STAT protein; post-translational protein modification; regulation of angiogenesis; regulation of cell shape; regulation of circadian sleep/wake cycle, non-REM sleep; response to amino acid; response to antibiotic; response to caffeine; response to calcium ion; response to cold; response to drug; response to electrical stimulus; response to glucocorticoid stimulus; response to heat; response to insulin stimulus; response to peptidoglycan; response to yeast

Disease: Arteriovenous Malformations Of The Brain; Inflammatory Bowel Disease 1; Kaposi Sarcoma, Susceptibility To; Rheumatoid Arthritis, Systemic Juvenile
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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