NP_001787.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
88,253 Da
NCBI Official Full Name
cadherin-8 preproprotein
NCBI Official Synonym Full Names
cadherin 8, type 2
NCBI Official Synonym Symbols
NCBI Protein Information
cadherin-8
UniProt Protein Name
Cadherin-8
UniProt Entry Name
CADH8_HUMAN
NCBI Summary for CDH8
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008]
UniProt Comments for CDH8
CDH8: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: plasma membrane; integral to membrane; nerve terminal
Molecular Function: calcium ion binding
Biological Process: synaptic transmission, glutamatergic; intercellular junction assembly and maintenance; response to cold; homophilic cell adhesion; cell adhesion
Research Articles on CDH8
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Products associated with CDH8 elisa kit
Pathways associated with CDH8 elisa kit
Diseases associated with CDH8 elisa kit
Organs/Tissues associated with CDH8 elisa kit
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