AAC50179.2
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,495 Da
NCBI Official Full Name
dopamine transporter
NCBI Official Synonym Full Names
solute carrier family 6 (neurotransmitter transporter), member 3
NCBI Protein Information
sodium-dependent dopamine transporter
UniProt Protein Name
Sodium-dependent dopamine transporter
UniProt Synonym Protein Names
Solute carrier family 6 member 3
UniProt Synonym Gene Names
UniProt Entry Name
SC6A3_HUMAN
NCBI Summary for DAT
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]
UniProt Comments for DAT
DAT: Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI). It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
Protein type: Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5p15.3
Cellular Component: cell soma; integral to plasma membrane; axon; cytoplasm; plasma membrane; integral to membrane
Molecular Function: protein binding; protease binding; dopamine binding; protein complex binding; monoamine transmembrane transporter activity; protein N-terminus binding; drug binding; dopamine:sodium symporter activity; dopamine transmembrane transporter activity; receptor binding
Biological Process: response to nicotine; lactation; response to drug; dopamine transport; response to cAMP; prepulse inhibition; dopamine catabolic process; regulation of dopamine metabolic process; monoamine transport; sensory perception of smell; locomotory behavior; dopamine biosynthetic process; positive regulation of multicellular organism growth; response to cocaine; synaptic transmission; response to ethanol; neurotransmitter transport; adenohypophysis development; transmembrane transport; response to iron ion; neurotransmitter biosynthetic process; aging
Disease: Parkinsonism-dystonia, Infantile; Tobacco Addiction, Susceptibility To
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Products associated with DAT elisa kit
Pathways associated with DAT elisa kit
Diseases associated with DAT elisa kit
Organs/Tissues associated with DAT elisa kit
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