NP_031465.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
174,948 Da
NCBI Official Full Name
ALK tyrosine kinase receptor
NCBI Official Synonym Full Names
anaplastic lymphoma kinase
NCBI Official Synonym Symbols
NCBI Protein Information
ALK tyrosine kinase receptor
UniProt Protein Name
ALK tyrosine kinase receptor
UniProt Synonym Protein Names
Anaplastic lymphoma kinase; CD_antigen: CD246
UniProt Entry Name
ALK_MOUSE
UniProt Comments for Alk
ALK: a tyrosine kinase of the ALK family. Plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. Translocated and expressed as a fusion protein in anaplastic lymphoma. About one third of large-cell lymphomas are caused by a t(2;5)(p23;q35) translocation that fuses ALK to nucleophosmin (NPM1A). Other cases caused by fusions of ALK to moesin, non-muscle myosin heavy chain 9, clathrin heavy chain and other genes. Several fusions also seen in inflammatory myofibroblastic tumors, and expression has been briefly noted in a range of tumors
Protein type: Protein kinase, TK; Oncoprotein; Kinase, protein; EC 2.7.10.1; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Alk family
Cellular Component: axon; integral to membrane; integral to plasma membrane; membrane; plasma membrane; protein complex
Molecular Function: ATP binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein-tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: activation of MAPK activity; nervous system development; neuron development; peptidyl-tyrosine phosphorylation; phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
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Products associated with Alk blocking peptide
Pathways associated with Alk blocking peptide
Diseases associated with Alk blocking peptide
Disease Name |
Pubmed Publications |
Respiratory Tract Diseases Antibodies |
>1389 publications with Alk and Respiratory Tract Diseases |
Lung Diseases Antibodies |
>1311 publications with Alk and Lung Diseases |
Lung Neoplasms Antibodies |
>1298 publications with Alk and Lung Neoplasms |
Lymphoma, Large-Cell, Anaplastic Antibodies |
>1213 publications with Alk and Lymphoma, Large-Cell, Anaplastic |
Carcinoma, Non-Small-Cell Lung Antibodies |
>861 publications with Alk and Carcinoma, Non-Small-Cell Lung |
Chromosome Aberrations Antibodies |
>366 publications with Alk and Chromosome Aberrations |
Lymphoma, Large B-Cell, Diffuse Antibodies |
>359 publications with Alk and Lymphoma, Large B-Cell, Diffuse |
Neuroblastoma Antibodies |
>228 publications with Alk and Neuroblastoma |
Adenocarcinoma of lung Antibodies |
>162 publications with Alk and Adenocarcinoma of lung |
Inflammation Antibodies |
>137 publications with Alk and Inflammation |
Organs/Tissues associated with Alk blocking peptide
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