AAB51134.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,411 Da
NCBI Official Full Name
MPIF-1
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 23
NCBI Official Synonym Symbols
CKb8; MIP3; Ckb-8; MIP-3; MPIF-1; SCYA23; Ckb-8-1; hmrp-2a; CK-BETA-8 [Similar Products]
NCBI Protein Information
C-C motif chemokine 23; C6 beta-chemokine; macrophage inflammatory protein 3; myeloid progenitor inhibitory factor 1; small inducible cytokine subfamily A (Cys-Cys), member 23
UniProt Protein Name
C-C motif chemokine 23
UniProt Synonym Protein Names
CK-beta-8; CKB-8; Macrophage inflammatory protein 3; MIP-3; Myeloid progenitor inhibitory factor 1; MPIF-1; Small-inducible cytokine A23
UniProt Synonym Gene Names
UniProt Entry Name
CCL23_HUMAN
NCBI Summary for MPIF-1
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
UniProt Comments for MPIF-1
CCL6: Shows chemotactic activity for monocytes, resting T- lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: extracellular space; extracellular region
Molecular Function: heparin binding; CCR1 chemokine receptor binding; chemokine activity
Biological Process: cellular calcium ion homeostasis; monocyte chemotaxis; negative regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; cell-cell signaling; immune response; chemotaxis; inflammatory response; signal transduction
Research Articles on MPIF-1
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Products associated with MPIF-1 elisa kit
Pathways associated with MPIF-1 elisa kit
Diseases associated with MPIF-1 elisa kit
Organs/Tissues associated with MPIF-1 elisa kit
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