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Mpo protein :: Myeloperoxidase Protein

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Catalog # MBS173160
Unit / Price
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  0.025 mg  /  $185 +1 FREE 8GB USB
  0.1 mg  /  $270 +1 FREE 8GB USB
  1 mg  /  $620 +1 FREE 8GB USB
Mpo protein
Product Name

Myeloperoxidase (Mpo), Protein

Popular Item
Full Product Name

Myeloperoxidase (MPO) Antigen, Human Neutrophil - pANCA

Product Synonym Names
MPO; pANCA; Myeloperoxidase Antigen (MPO), pANCA - Human - >=96% (SDS-PAGE) - Liquid
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P05164
Purity/Purification
>= 96% (SDS-PAGE)
Form/Format
Liquid
Appearance: Clear, greenish Liquid
Source
Human Neutrophils
EC Number
1.11.2.2
Unit Definition
One unit of Myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25 degree C.
Specific Activity
>= 1,000 U/mg protein
RZ Value
>= 0.8 (A430/A280)
Recertification
2 years
Protein
1.0 - 2.0 mg/mL (A280, E0.1%=1.45)
CAS Number
9003-99-0
Activity
>= 1,000 U/mL
Preparation and Storage
2-8 degree C
Other Notes
Small volumes of Mpo protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Mpo protein
MyBioSource is the largest primary manufacturer of Myeloperoxidase (MPO) enzymes for medical research and diagnostic manufacturing globally.

Custom preparations, technical support, bulk quantities and aliquoting available.

Rz is an abbreviation for Reinheitszahl (purity number). It is the ratio of absorbance at 430 nm (heme)/ 280 nm (total protein). It is a measure of the purity of the enzyme. Anything above 0.8 is highly pure.

MPO is a peroxidase enzyme occurs the most in neutrophil granulocytes (a subtype of white blood cells). It is a lysosomal protein stored in azurophilic granules of the neutrophil. Myeloperoxidase has a green heme pigment and is found in pus and some forms of mucus. It is recognized as an important factor in many inflammatory diseases such as cardiovascular and neurological diseases. MPO-specific imaging agents would thus be highly useful to diagnose early disease, monitor disease progression, and quantify treatment effects.
NCBI/Uniprot data below describe general gene information for Mpo. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,182 Da[Similar Products]
NCBI Official Full Name
myeloperoxidase
NCBI Official Synonym Full Names
myeloperoxidase
NCBI Official Symbol
NCBI Official Synonym Symbols
mKIAA4033
  [Similar Products]
NCBI Protein Information
myeloperoxidase
UniProt Protein Name
Myeloperoxidase
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
PERM_MOUSE
UniProt Comments for Mpo
MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.11.2.2; Oxidoreductase

Chromosomal Location of Human Ortholog: 17q23.1

Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule

Molecular Function: heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding

Biological Process: respiratory burst during defense response; response to food; removal of superoxide radicals; hydrogen peroxide catabolic process; response to mechanical stimulus; defense response; response to yeast; response to lipopolysaccharide; response to oxidative stress; defense response to fungus; aging; negative regulation of apoptosis

Disease: Myeloperoxidase Deficiency; Alzheimer Disease
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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