NP_006030.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
C-type mannose receptor 2
NCBI Official Synonym Full Names
mannose receptor C type 2
NCBI Official Synonym Symbols
CD280; UPARAP; CLEC13E; ENDO180 [Similar Products]
NCBI Protein Information
C-type mannose receptor 2
UniProt Protein Name
C-type mannose receptor 2
UniProt Synonym Protein Names
C-type lectin domain family 13 member E; Endocytic receptor 180; Macrophage mannose receptor 2; Urokinase-type plasminogen activator receptor-associated protein; UPAR-associated protein; Urokinase receptor-associated protein; CD_antigen: CD280
UniProt Synonym Gene Names
CLEC13E; ENDO180; KIAA0709; UPARAP; UPAR-associated protein; Urokinase receptor-associated protein [Similar Products]
NCBI Summary for MRC2
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
UniProt Comments for MRC2
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
Product References and Citations for anti-MRC2 antibody
Behrendt N., J. Biol. Chem. 275:1993-2002(2000). Sheikh H., J. Cell Sci. 113:1021-1032(2000). Howard M.J., J. Biol. Chem. 277:32320-32331(2002).
Research Articles on MRC2
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Pathways associated with anti-MRC2 antibody
Diseases associated with anti-MRC2 antibody
Organs/Tissues associated with anti-MRC2 antibody
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