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Mre11a recombinant protein :: Double-strand break repair protein MRE11A (Mre11a) Recombinant Protein

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Catalog # MBS1412512
Unit / Price
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  0.05 mg (E-Coli)  /  $1,135 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $1,150 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,385 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,530 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,565 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,625 +2 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,690 +2 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,775 +2 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $2,005 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,545 +3 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,570 +3 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,600 +3 FREE 8GB USB
  1 mg (Yeast)  /  $2,795 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,975 +4 FREE 8GB USB
Mre11a recombinant protein
Product Name

Double-strand break repair protein MRE11A (Mre11a), Recombinant Protein

Full Product Name

Recombinant Rat Double-strand break repair protein MRE11A (Mre11a)

Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-706aa, Full Length of Mature Protein
Sequence
SPTDPLDDED TFKILVATDI HLGFMEKDAV RGNDTFVTFD EILRLALENE VDFILLGGDL FHENKPSRKT LHSCLELLRK YCMGDRPVQF EIISDQSVNF GFSKFPWVNY RDGNLNISIP VFSIHGNHDD PTGADALCAL DVLSCAGFVN HFGRSMSVEK VDISPVLLQK GSTKLALYGL GSIPDERLYR MFVNKKVTML RPKEDENSWF NLFVIHQNRS KHGSTNFIPE QFLDDFIDLV IWGHEHECKI GPTRNEQQLF YVSQPGSSVV TALSPGETVK KHVGLLRVKG RKMNMQKLPL RTVRQFFMED VVLANHPSLF NPDNPKVTQA IQSFCLEKIE EMLDSAERER LGNPQQPEKP LIRLRVDYSG GFEPFNVLRF SQKFVDRVAN PKDVIHFFRH REQKGKTGEE INFGKLIIKP ASEGTTLRVE DLVKQYFQTA EKNVQLSLLT ERGMGEAVQE FVDKEEKDAI EELVKYQLEK TQRFLKERHI DALEDKIDEE VRRFRESRQR NTNEEDDEVR EAMSRARALR SQSENAASAF SADDLSFDIT EQTADDSDDS QSAVPSRGRG RGRGRRGGRG QSTAPRGGSQ RGRDTGLGIS TRGRSSKATA STSRNMSIID AFRSTRQQPS RNVATKNYSE TIEVDESDDD DSFPTSSRAD QRWSGTAPSK RMSQSQTAKG VDFESDEDDD DDPFMSGSCP RRNRR
3D Structure
ModBase 3D Structure for Q9JIM0
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rat
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Mre11a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Mre11a recombinant protein
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3 to 5 exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3 to 5 exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
NCBI/Uniprot data below describe general gene information for Mre11a. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
80,122 Da
NCBI Official Full Name
double-strand break repair protein MRE11
NCBI Official Synonym Full Names
MRE11 homolog A, double strand break repair nuclease
NCBI Official Symbol
Mre11a  [Similar Products]
NCBI Official Synonym Symbols
Mre11
  [Similar Products]
NCBI Protein Information
double-strand break repair protein MRE11; double-strand break repair protein MRE11A
UniProt Protein Name
Double-strand break repair protein MRE11
UniProt Synonym Protein Names
Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A
UniProt Gene Name
Mre11  [Similar Products]
UniProt Synonym Gene Names
Mre11a; MRE11 homolog 1; MRE11 homolog A  [Similar Products]
NCBI Summary for Mre11a
may play a role in regulation of cardiomyocyte proliferation [RGD, Feb 2006]
UniProt Comments for Mre11a
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with Mre11a recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >4 publications with Mre11a and Prostate
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