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MTA1 cdna clone

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Catalog # MBS1274868
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
MTA1 cdna clone
Product Name

MTA1, cDNA Clone

Popular Item
Full Product Name

MTA1 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgaagacca ggcaggcttt ctatctgcac acgacgaagc tgacgcggat cgcccggcgc ctgtgccgtg agatcctgcg cccgtggcac gctgcgcggc acccctacct gcccatcaac agcgcggcca tcaaggccga gtgcacggcg cggctgcccg aagcctccca gagcccgctg gtgctgaagc aggcggtacg caagccgctg gaagccgtgc ttcggtatct tgagacccac ccccgccccc ccaagcctga ccccgtgaaa agcgtgtcca gcgtgctcag cagcctgacg cccgccaagg tggcccccgt catcaacaac ggctccccca ccatcctggg caagcgcagc tacgagcagc acaacggggt ggacggcaac atgaagaagc gcctcttgat gcccagtagg ggcacttacc tgggtctggc aaaccacgga cagaccaggc acatgggacc aagccggaac ctcctgctca acgggaagtc ctaccccacc aaagtgcgcc tgatccgggg gggctccctg cccccagtca agcggcggcg gatgaactgg atcgacgccc cggatgacgt gttctacatg gccacagagg agaccaggaa gatccgcaag ctgctctcat cctcggaaac caagcgtgct gcccgccggc cctacaagcc catcgccctg cgccagagcc aggccctgcc gccgcggcca ccgccacctg cgcccgtcaa cgacgagccc atcgtcatcg aggactag
OMIM
603526
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of MTA1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MTA1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
79,192 Da
NCBI Official Full Name
Homo sapiens metastasis associated 1, mRNA
NCBI Official Synonym Full Names
metastasis associated 1
NCBI Official Symbol
NCBI Protein Information
metastasis-associated protein MTA1
UniProt Protein Name
Metastasis-associated protein MTA1
Protein Family
UniProt Gene Name
UniProt Entry Name
MTA1_HUMAN
NCBI Summary for MTA1
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
UniProt Comments for MTA1
MTA1: metastasis-associated protein. A component of the NuRD ATP-dependent chromatin remodeling and histone deacetylase complex. Interacts with HDAC1. Expressed at high levels in metastatic cells. Two alternatively spliced isoforms have been described. The long isoform is a co-repressor of estrogen receptor (ER). The short isoform binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.

Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 14q32.3

Cellular Component: cytoplasm; intracellular membrane-bound organelle; microtubule; nuclear envelope; nucleoplasm; nucleus

Molecular Function: histone deacetylase activity; protein binding; transcription coactivator activity; transcription corepressor activity

Biological Process: circadian regulation of gene expression; double-strand break repair; entrainment of circadian clock by photoperiod; locomotor rhythm; proteasomal ubiquitin-dependent protein catabolic process; protein sumoylation; regulation of gene expression, epigenetic; regulation of inflammatory response; response to ionizing radiation; response to lipopolysaccharide; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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