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MTAP cdna clone

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Catalog # MBS1275903
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
MTAP cdna clone
Product Name

MTAP, cDNA Clone

Also Known As

MTAP cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
465
Sequence
atggcctctg gcaccaccac caccgccgtg aagattggaa taattggtgg aacaggcctg gatgatccag aaattttaga aggaagaact gaaaaatatg tggatactcc atttggcaag ccatctgatg ccttaatttt ggggaagata aaaaatgttg attgcatcct ccttgcaagg catggaaggc agcacaccat catgccttca aaggtcaact accaggcgaa catctgggct ttgaaggaag agggctgtac acatgtcata gtgaccacag cttgtggctc cttgagggag gagattcagc ccggcgatat tgtcattatt gatcagttca ttgacagcca tgtaagacgt gcctgcttcc ccttcacctt ccatcatgat tgtttccaga gacctcccca gaagccaagc agaagccact gtgtttcctg tgcaacctgc agaaccatga gctaa
OMIM
112250
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of MTAP cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MTAP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,278 Da
NCBI Official Full Name
Homo sapiens methylthioadenosine phosphorylase, mRNA
NCBI Official Synonym Full Names
methylthioadenosine phosphorylase
NCBI Official Symbol
NCBI Official Synonym Symbols
BDMF; MSAP; DMSFH; LGMBF; DMSMFH; c86fus; HEL-249
  [Similar Products]
NCBI Protein Information
S-methyl-5'-thioadenosine phosphorylase
UniProt Protein Name
S-methyl-5'-thioadenosine phosphorylase
UniProt Synonym Protein Names
5'-methylthioadenosine phosphorylase
UniProt Gene Name
UniProt Synonym Gene Names
MTA phosphorylase; MTAP; MTAPase  [Similar Products]
UniProt Entry Name
MTAP_HUMAN
NCBI Summary for MTAP
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]
UniProt Comments for MTAP
MTAP: Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. Homotrimer. Ubiquitously expressed. Inhibited by 5'-methylthiotubercin and 5'- chloroformycin. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Protein type: EC 2.4.2.28; Amino Acid Metabolism - cysteine and methionine; Phosphorylase; Transferase

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: cytoplasm; cytosol

Molecular Function: phosphorylase activity; protein binding; S-methyl-5-thioadenosine phosphorylase activity

Biological Process: methionine salvage; nicotinamide riboside catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; purine salvage
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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