BC130579
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
64,702 Da
NCBI Official Full Name
Homo sapiens myotubularin related protein 7, mRNA
NCBI Official Synonym Full Names
myotubularin related protein 7
NCBI Protein Information
myotubularin-related protein 7
UniProt Protein Name
Myotubularin-related protein 7
UniProt Entry Name
MTMR7_HUMAN
NCBI Summary for MTMR7
This gene encodes a member of the myotubularin family of tyrosine/dual-specificity phosphatases. The encoded protein is characterized by four distinct domains that are conserved among all members of the myotubularin family: the glucosyltransferase, Rab-like GTPase activator and myotubularins domain, the Rac-induced recruitment domain, the protein tyrosine phosphatases and dual-specificity phosphatases domain and the suppressor of variegation 3-9, enhancer-of-zeste, and trithorax interaction domain. This protein dephosphorylates the target substrates phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Mar 2009]
UniProt Comments for MTMR7
MTMR7: a protein of the myotubularin family. Myotubularins are a family of unique protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as physiological substrates. Myotubularins specifically dephosphorylate phosphatidylinositol 3-phosphate [PI(3)P] and phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2], generating phosphatidylinositol and phosphatidylinositol 5-phosphate [PI(5)P], respectively. PI(3)P and PI(3,5)P2 regulate membrane trafficking events through the recruitment of effector proteins containing the lipid-binding domains FYVE, PH, and ENTH. MTMR5, -9, -10, -11, -12, -13 are catalytically inactive lipid phosphatases but may mediate important protein-protein interactions. Expressed at high levels in the brain. Two alternatively spliced human isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Phosphatase, lipid; EC 3.1.3.-; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 8p22
Cellular Component: cytosol
Molecular Function: phosphatidylinositol-3-phosphatase activity; protein binding
Biological Process: phosphatidylinositol biosynthetic process; protein amino acid dephosphorylation
Research Articles on MTMR7
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Pathways associated with MTMR7 cdna clone
Diseases associated with MTMR7 cdna clone
Organs/Tissues associated with MTMR7 cdna clone
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