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MVK cdna clone

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Catalog # MBS1266849
Unit / Price
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
MVK cdna clone
Product Name

MVK, cDNA Clone

Popular Item
Full Product Name

MVK cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgttgtcag aagtcctact ggtgtctgct ccggggaaag tcatccttca tggagaacat gccgtggtac atggcaaggt agcactggct gtatccttga acttgagaac attcctccgg cttcaacccc acagcaatgg gaaagtggac ctcagcttac ccaacattgg tatcaagcgg gcctgggatg tggccaggct tcagtcactg gacacaagct ttctggagca aggtgatgtc acaacaccca cctcagagca agtggagaag ctaaaggagg ttgcaggctt gcctgacgac tgtgctgtca ccgagcgcct ggctgtgctg gcctttcttt acttatacct gtccatctgc cggaagcaga gggccctgcc gagcctggat atcgtagtgt ggtcggagct gccccccggg gcgggcttgg gctccagcgc cgcctactcg gtgtgtctgg cagcagccct cctgactgtg tgcgaggaga tcccaaaccc gctgaaggac ggggattgcg tcaacaggtg gaccaaggag gatttggagc taattaacaa gtgggccttc caaggggaga gaatgattca cgggaacccc tccggagtgg acaatgctgt cagcacctgg ggaggagccc tccgatacca tcaagggaag atttcatcct taaagaggtc gccagctctc cagatcctgc tgaccaacac caaagtccct cgcaatacca gggcccttgt ggctggcgtc agaaacaggc tgctcaagtt cccagagatc gtggcccccc tcctgacctc aatagatgcc atctccctgg agtgtgagcg cgtgctggga gagatggggg aagccccagc cccggagcag tacctcgtgc tggaagagct cattgacatg aaccagcacc atctgaatgc cctcggcgtg ggccacgcct ctctggacca gctctgccag gtgaccaggg cccgcggact tcacagcaag ctgactggcg caggcggtgg tggctgtggc atcacactcc tcaagccagg gctggagcag ccagaagtgg aggccacgaa gcaggccctg accagctgtg gctttgactg cttggaaacc agcatcggtg cccccggcgt ctccatccac tcagccacct ccctggacag ccgagtccag caagccctgg atggcctctg a
OMIM
175900
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MVK cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MVK. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Related Accession #
Molecular Weight
42,451 Da
NCBI Official Full Name
Homo sapiens mevalonate kinase, mRNA
NCBI Official Synonym Full Names
mevalonate kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
MK; LRBP; MVLK; POROK3
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NCBI Protein Information
mevalonate kinase
UniProt Protein Name
Mevalonate kinase
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
KIME_HUMAN
NCBI Summary for MVK
This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Comments for MVK
MVK: May be a regulatory site in cholesterol biosynthetic pathway. Defects in MVK are the cause of mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia. Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS). HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

Protein type: Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.7.1.36; RNA-binding; Kinase, other; Translation

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: cytosol; peroxisome

Molecular Function: identical protein binding; mevalonate kinase activity; protein binding

Biological Process: cholesterol biosynthetic process; isoprenoid biosynthetic process; negative regulation of inflammatory response

Disease: Hyper-igd Syndrome; Mevalonic Aciduria; Porokeratosis 3, Disseminated Superficial Actinic Type
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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