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anti-MYC antibody :: Human anti-Human c-myc epitope tag Antibody

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Catalog # MBS488005
Unit / Price
  0.2 mg  /  $425 +1 FREE 8GB USB
anti-MYC antibody
Product Name

c-myc epitope tag, Antibody

Also Known As

Anti-c-myc epitope tag [9E10]

Product Synonym Names
Proto-oncogene c-Myc; Transcription factor p64; Class E basic helix-loop-helix protein 39; BHLHE39; cmyc
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
439
OMIM
3D Structure
ModBase 3D Structure for P01106
Isotype
IgG2, kappa
Clone Number
9E10
Host
Human
Species Reactivity
Human
Specificity
Epitope sequence, EQKLISEEDL, located in aa 410-419 of human c-myc protein.
Purity/Purification
Protein A Affinity Purified
Form/Format
PBS with preservative (0.02% Proclin 300)
Buffer Composition
PBS only.
Immunogen
A synthetic peptide corresponding to aa 408-439 from C-terminus of human c-myc.
Chimeric Use Statement
This is a chimeric human antibody, based on the original mouse IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Preparation and Storage
Store at 4 degree C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20 degree C.
Other Notes
Small volumes of anti-MYC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MYC antibody
Recombinant monoclonal antibody to c-myc epitope tag. Manufactured using a Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 9E10. This is a chimeric human antibody, based on the original mouse IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Product Categories/Family for anti-MYC antibody
Applications Tested/Suitable for anti-MYC antibody
Immunohistochemistry (IHC) Formalin/Paraffin, Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for MYC. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,565 Da[Similar Products]
NCBI Official Full Name
Myc proto-oncogene protein
NCBI Official Synonym Full Names
v-myc avian myelocytomatosis viral oncogene homolog
NCBI Official Symbol
NCBI Official Synonym Symbols
MRTL; MYCC; c-Myc; bHLHe39
  [Similar Products]
NCBI Protein Information
myc proto-oncogene protein
UniProt Protein Name
Myc proto-oncogene protein
UniProt Synonym Protein Names
Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
BHLHE39; bHLHe39  [Similar Products]
UniProt Entry Name
MYC_HUMAN
NCBI Summary for MYC
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for MYC
Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.

Protein type: DNA-binding; Nucleolus; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 8q24.21

Cellular Component: cytosol; nucleolus; nucleoplasm; nucleus; protein complex

Molecular Function: DNA binding; protein binding; protein complex binding; transcription factor activity; transcription factor binding

Biological Process: cell cycle arrest; cellular iron ion homeostasis; chromatin remodeling; chromosome organization and biogenesis; MAPKKK cascade; negative regulation of apoptosis; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; positive regulation of caspase activity; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of telomerase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of gene expression; regulation of telomere maintenance; response to DNA damage stimulus; response to drug; response to gamma radiation; ureteric bud branching; Wnt receptor signaling pathway through beta-catenin

Disease: Burkitt Lymphoma
Product References and Citations for anti-MYC antibody
Evan GI, Lewis GK, Ramsay G, Bishop JM. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol. 1985 Dec; 5(12):3610-6. PMID:3915782

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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